Tramadol and Drospirenone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Drospirenone (drospirenone). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Drospirenone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Drospirenone?

Drospirenone has active ingredients of drospirenone. eHealthMe is studying from 603 Drospirenone users. Check the latest studies of Drospirenone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

20 people who take Tramadol and Drospirenone together, and have interactions are studied.

Tramadol and Drospirenone drug interactions.

What are the common drug interactions of Tramadol and Drospirenone, by gender? *:

female:

Headache (pain in head)
Blood cholesterol increased
Weight decreased
Acne (skin problems that cause pimples)
Amylase increased
Anxiety
Arrhythmia (irregular heartbeat)
Blood pressure increased
Depression
Diarrhoea

male:

n/a

What are the common drug interactions of Tramadol and Drospirenone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Amylase increased
Pancreatitis (inflammation of pancreas)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Blood cholesterol increased
Blood pressure fluctuation
Breast cancer
Device related infection
Post procedural infection
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Weight decreased
Psoriasis (immune-mediated disease that affects the skin)

40-49:

Depression
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Headache (pain in head)
Abdominal pain
Acne (skin problems that cause pimples)
Drug ineffective
Anxiety

50-59:

Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

60+:

n/a

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 40.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 40.00%
Nausea (feeling of having an urge to vomit): 3 people, 15.00%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 2 people, 10.00%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 10.00%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 10.00%
Back Pain: 2 people, 10.00%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 10.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 10.00%
Birth Control: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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