Tramadol and Fentanyl-25 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Fentanyl-25 (fentanyl). Common drug interactions include cyanosis among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Fentanyl-25. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Fentanyl-25?

Fentanyl-25 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 413 Fentanyl-25 users. Check the latest studies of Fentanyl-25.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

15 people who take Tramadol and Fentanyl-25 together, and have interactions are studied.

Tramadol and Fentanyl-25 drug interactions.

What are the common drug interactions of Tramadol and Fentanyl-25, by gender? *:

female:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Multiple drug overdose
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Unresponsive to stimuli
Drug exposure during pregnancy
Fall
Oedema peripheral (superficial swelling)
Premature rupture of membranes
Respiratory depression (respiration has a rate below 12 breaths)

male:

Confusional state
Consciousness fluctuating
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Delusion (a false belief or opinion)
Diarrhoea
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Gamma-glutamyltransferase increased

What are the common drug interactions of Tramadol and Fentanyl-25, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug exposure during pregnancy
Fall
Premature rupture of membranes
Uterine contractions during pregnancy
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Nasopharyngitis (inflammation of the nasopharynx)
Normal newborn
Premature baby
Sacroiliitis (an inflammation of the sacroiliac joint)

30-39:

n/a

40-49:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Multiple drug overdose
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Unresponsive to stimuli
Respiratory depression (respiration has a rate below 12 breaths)
Oedema peripheral (superficial swelling)
Pain in extremity
Respiratory failure (inadequate gas exchange by the respiratory system)
Stress

50-59:

n/a

60+:

Confusional state
Consciousness fluctuating
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Hyperhidrosis (abnormally increased sweating)
Oedema peripheral (superficial swelling)
Oesophageal spasm (contraction of oesophagus)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Depressed level of consciousness

What are the existing conditions these people have? *

Procedural Pain: 3 people, 20.00%
Back Pain: 3 people, 20.00%
Rib Fracture: 2 people, 13.33%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 6.67%
Sinusitis (inflammation of sinus): 1 person, 6.67%
Respiratory Tract Infection: 1 person, 6.67%
Pain In Extremity: 1 person, 6.67%
Neck Pain: 1 person, 6.67%
Infection: 1 person, 6.67%
Depression: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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