Tramadol and Gilotrif drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Gilotrif (afatinib dimaleate). Common drug interactions include rhinorrhoea among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Gilotrif. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Gilotrif?

Gilotrif has active ingredients of afatinib dimaleate. eHealthMe is studying from 6,055 Gilotrif users. Check the latest studies of Gilotrif.

On Jul, 13, 2026

67 people who take Tramadol and Gilotrif together, and have interactions are studied.

Tramadol and Gilotrif drug interactions.

What are the common drug interactions of Tramadol and Gilotrif, by gender? *:

female:

Rhinorrhoea (watery mucus discharge from the nose)
Acne (skin problems that cause pimples)
Onychoclasis (breaking of the nails)
Vision blurred
Alopecia (absence of hair from areas of the body)
Corneal lesion (an injury to the living tissue of cornea)
Feeding disorder (when children refuse to eat certain food groups)
Fluid retention (an abnormal accumulation of fluid in the blood)
Staphylococcal infection (an infection with staphylococcus bacteria)
Swelling

male:

Diarrhoea
Rash
Acne (skin problems that cause pimples)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Pleural effusion (water on the lungs)
Inflammation
Mouth injury
Swollen tongue (swelling of tongue)
Dyspnoea (difficult or laboured respiration)
Dyspepsia (indigestion)

What are the common drug interactions of Tramadol and Gilotrif, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Malignant neoplasm progression (cancer tumour came back)
Metastases to meninges (cancer spreads to meninges)
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

n/a

40-49:

Pruritus (severe itching of the skin)
Rash
Skin irritation
Stomatitis (inflammation of mucous membrane of mouth)
Drug ineffective
Anxiety

50-59:

Dyspnoea (difficult or laboured respiration)
Emotional distress
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Psoriasis (immune-mediated disease that affects the skin)
Rash pustular (redness with pustules)
Suicidal ideation
Swelling face
Vulvovaginal rash

60+:

Diarrhoea
Rash
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Myalgia (muscle pain)
Pruritus (severe itching of the skin)
Acne (skin problems that cause pimples)
Abdominal pain upper
Dehydration (dryness resulting from the removal of water)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 40 people, 59.70%
High Blood Pressure: 14 people, 20.90%
Lung Neoplasm Malignant (cancer tumour of lung): 13 people, 19.40%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 7 people, 10.45%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 6 people, 8.96%
Anaemia (lack of blood): 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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