Tramadol and Hectorol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Hectorol (doxercalciferol). Common drug interactions include renal impairment among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Hectorol. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Hectorol?

Hectorol has active ingredients of doxercalciferol. eHealthMe is studying from 1,815 Hectorol users. Check the latest studies of Hectorol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

58 people who take Tramadol and Hectorol together, and have interactions are studied.

Tramadol and Hectorol drug interactions.

What are the common drug interactions of Tramadol and Hectorol, by gender? *:

female:

Renal impairment (severely reduced kidney function)
White blood cell count decreased
Renal failure (kidney dysfunction)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Partner stress
Social problem
Affective disorder (mental disorder)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Blood pressure decreased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Tramadol and Hectorol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hypertension (high blood pressure)
Nephrolithiasis (calculi in the kidneys)
Cholecystitis chronic (long lasting infection of gallbladder)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Cardiac failure congestive

30-39:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Gait disturbance
Hyperkalaemia (damage to or disease of the kidney)

40-49:

Asthenia (weakness)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diarrhoea
Dizziness
Dysstasia (difficulty in standing)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Vomiting
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arrhythmia (irregular heartbeat)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Anxiety
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Affective disorder (mental disorder)
Asthenia (weakness)
Depression
Dyspnoea (difficult or laboured respiration)
Emotional distress

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Gout (uric acid crystals building up in the body)
Loss of consciousness
Peritoneal haemorrhage (peritoneal bleeding)
Renal haemangioma (kidney tumour filled with blood)
Thermal burn (burn by heat)
Vomiting
Abdominal pain
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 31 people, 53.45%
High Blood Pressure: 22 people, 37.93%
Thyroid Diseases: 10 people, 17.24%
Depression: 10 people, 17.24%
Infection: 10 people, 17.24%
Stress And Anxiety: 9 people, 15.52%
Blood Pressure Abnormal: 9 people, 15.52%
Diabetes: 8 people, 13.79%
Gout (uric acid crystals building up in the body): 8 people, 13.79%
Parathyroid Disorder: 7 people, 12.07%

* Approximation only. Some reports may have incomplete information.

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