Tramadol and Para drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Para (para - aminobenzoic acid (paba)). Common drug interactions include red blood cell sedimentation rate increased among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Para. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Para?

Para has active ingredients of para - aminobenzoic acid (paba). eHealthMe is studying from 2,194 Para users. Check the latest studies of Para.

On Jul, 16, 2026

81 people who take Tramadol and Para together, and have interactions are studied.

What are the common drug interactions of Tramadol and Para, by gender? *:

female:

Red blood cell sedimentation rate increased
Visual impairment
Adjustment disorder with depressed mood
Blood cholesterol increased
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Dislocation of vertebra
Dyspepsia (indigestion)
Headache (pain in head)
Rheumatoid factor positive

male:

Neuropathy peripheral (surface nerve damage)
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Oxygen saturation decreased
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Acute respiratory failure
Bradycardia (abnormally slow heart action)

What are the common drug interactions of Tramadol and Para, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Diarrhoea
Muscle spasms (muscle contraction)
Neuropathy peripheral (surface nerve damage)
Pulmonary embolism (blockage of the main artery of the lung)
Rash pruritic (redness with itching)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Acute respiratory failure

30-39:

Oxygen saturation decreased
Respiratory failure (inadequate gas exchange by the respiratory system)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Altered state of consciousness (altered state of mind)
Balance disorder
Bradycardia (abnormally slow heart action)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Confusional state
Dizziness

40-49:

Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Infection
Infusion related reaction
Irritable bowel syndrome
Pyrexia (fever)
Confusional state
Anti-cyclic citrullinated peptide antibody positive
Hepatic enzyme increased
Drug ineffective
Fatigue (feeling of tiredness)

50-59:

Mobility decreased (ability to move is reduced)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Stress
Thrombosis (formation of a blood clot inside a blood vessel)
Weight increased
Bradycardia (abnormally slow heart action)
Drug abuse
Faecaloma (hard mass of fecal matter)
Fall
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 42 people, 51.85%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 42 people, 51.85%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 34 people, 41.98%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 33 people, 40.74%
Psoriasis (immune-mediated disease that affects the skin): 26 people, 32.10%
Inflammation: 25 people, 30.86%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 21 people, 25.93%
Synovitis (inflammation of the synovial membrane): 20 people, 24.69%
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 20 people, 24.69%
Fever: 20 people, 24.69%

* Approximation only. Some reports may have incomplete information.

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