Tramadol and Pazeo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Pazeo (olopatadine hydrochloride). Common drug interactions include anxiety among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Pazeo. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Pazeo?

Pazeo has active ingredients of olopatadine hydrochloride. eHealthMe is studying from 1,256 Pazeo users. Check the latest studies of Pazeo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

47 people who take Tramadol and Pazeo together, and have interactions are studied.

What are the common drug interactions of Tramadol and Pazeo, by gender? *:

female:

Anxiety
Arthralgia (joint pain)
Headache (pain in head)
Memory impairment
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Eye irritation
Eye pruritus (eye itching)
Nasal disorder (diseases of nose)
Ocular hyperaemia (an abnormally large amount of blood in eye)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Headache (pain in head)
Libido decreased (loss of interest in sex)
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Abdominal adhesions (inflammation of abdomen)
Decreased appetite

What are the common drug interactions of Tramadol and Pazeo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Surgery

40-49:

Anxiety
Memory impairment
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Headache (pain in head)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasal disorder (diseases of nose)
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Weight decreased

50-59:

Chronic kidney disease
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal adhesions (inflammation of abdomen)
Abdominal pain upper
Epistaxis (bleed from the nose)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Groin pain
Headache (pain in head)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Intervertebral disc disorder (spinal disc disorder)

60+:

Arthralgia (joint pain)
Diarrhoea
Headache (pain in head)
Infection
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Lung hyperinflation (inspiration of more than normal)
Pruritus (severe itching of the skin)
Vasoconstriction (constriction of blood vessels, which increases blood pressure)
Vomiting
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 19.15%
Asthma: 8 people, 17.02%
Nausea (feeling of having an urge to vomit): 6 people, 12.77%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 12.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.77%
High Blood Pressure: 6 people, 12.77%
Stress And Anxiety: 5 people, 10.64%
High Blood Cholesterol: 5 people, 10.64%
Depression: 5 people, 10.64%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 4 people, 8.51%

* Approximation only. Some reports may have incomplete information.

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