Tramadol and Propylthiouracil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Propylthiouracil (propylthiouracil). Common drug interactions include chronic kidney disease among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Propylthiouracil. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Propylthiouracil?

Propylthiouracil has active ingredients of propylthiouracil. It is often used in hyperthyroidism. eHealthMe is studying from 2,545 Propylthiouracil users. Check the latest studies of Propylthiouracil.

On Jul, 08, 2026

48 people who take Tramadol and Propylthiouracil together, and have interactions are studied.

Tramadol and Propylthiouracil drug interactions.

What are the common drug interactions of Tramadol and Propylthiouracil, by gender? *:

female:

Chronic kidney disease
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Cough
Decreased activity
Dry eye (lack of adequate tears)
Emotional distress

male:

Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Drug dependence
Drug ineffective
Faecal incontinence (a lack of control over passing stool)
Flatulence (flatus expelled through the anus)
Osteopenia (a condition where bone mineral density is lower than normal)
Intervertebral disc protrusion (spinal disc protrusion)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Death

What are the common drug interactions of Tramadol and Propylthiouracil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injury
Cough
Dry eye (lack of adequate tears)
Head discomfort
Sinusitis (inflammation of sinus)
Drug hypersensitivity
Cartilage injury
Disability
Psychiatric symptom
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Decreased activity
Emotional distress
Immobile (not moving)
Osteoporosis (bones weak and more likely to break)
Quality of life decreased
Rib fracture
Anaemia (lack of blood)

50-59:

Abdominal pain
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Atrioventricular block complete (heart block complete)
Blood thyroid stimulating hormone decreased

60+:

Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Decreased interest
Diarrhoea
Dizziness
Gait disturbance
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.50%
Lung Cancer - Non-Small Cell (lung cancer): 5 people, 10.42%
High Blood Pressure: 5 people, 10.42%
High Blood Cholesterol: 5 people, 10.42%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.33%
Sleep Disorder: 3 people, 6.25%
Peripheral Arterial Occlusive Disease (reproducible ischemic muscle pain): 3 people, 6.25%
Migraine (headache): 3 people, 6.25%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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