Tramadol and Relistor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Relistor (methylnaltrexone bromide). Common drug interactions include injection site pain among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Relistor. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Relistor?

Relistor has active ingredients of methylnaltrexone bromide. eHealthMe is studying from 1,659 Relistor users. Check the latest studies of Relistor.

On Jul, 03, 2026

39 people who take Tramadol and Relistor together, and have interactions are studied.

Tramadol and Relistor drug interactions.

What are the common drug interactions of Tramadol and Relistor, by gender? *:

female:

Injection site pain
Weight increased
Drug ineffective
Anxiety
Chronic kidney disease
Oropharyngeal pain
Constipation
Diarrhoea
Chest pain
Cough

male:

Drug ineffective
Muscle spasms (muscle contraction)
Pain in extremity
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Post procedural swelling
Postoperative wound complication
Streptococcal infection
Tendonitis (a condition that causes pain and swelling of tendons)
Pneumonia
Renal pain (kidney pain)

What are the common drug interactions of Tramadol and Relistor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cerebrospinal fluid leakage
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Pseudomeningocele (abnormal collection of cerebrospinal fluid)
Swelling

30-39:

n/a

40-49:

Drug ineffective
Injection site oedema
Injection site pain
Weight increased
Anxiety
Mood swings (an extreme or rapid change in mood)
Muscle spasms (muscle contraction)

50-59:

Injection site pain
Oropharyngeal pain
Anxiety
Chest pain
Cough
Diarrhoea
Localised infection (infection at the single location)
Tooth infection
Weight increased
Abdominal distension

60+:

Drug ineffective
Chronic kidney disease
Gastrointestinal mucosal exfoliation (mucous membrane comes out and new takes place in gastrointestinal tract)
Headache (pain in head)
Lethargy (tiredness)
Mucous stools (mucous with stool)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Neck pain
Retching (strong involuntary effort to vomit)

What are the existing conditions these people have? *

Constipation: 9 people, 23.08%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 20.51%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 17.95%
High Blood Pressure: 5 people, 12.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 12.82%
Depression: 3 people, 7.69%
High Blood Cholesterol: 3 people, 7.69%
Stress And Anxiety: 3 people, 7.69%
Oedema (fluid collection in tissue): 3 people, 7.69%
Muscle Spasms (muscle contraction): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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