Tramadol and Smoflipid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Smoflipid (lipid injectable emulsion (soybean;mct;olive;fish)). Common drug interactions include pneumonia among females and delirium among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Smoflipid. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Smoflipid?

Smoflipid has active ingredients of lipid injectable emulsion (soybean;mct;olive;fish). eHealthMe is studying from 681 Smoflipid users. Check the latest studies of Smoflipid.

On Jul, 20, 2026

17 people who take Tramadol and Smoflipid together, and have interactions are studied.

Tramadol and Smoflipid drug interactions.

What are the common drug interactions of Tramadol and Smoflipid, by gender? *:

female:

Pneumonia
Arthralgia (joint pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Peripheral swelling
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Pain in extremity
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Nausea (feeling of having an urge to vomit)
Occipital neuralgia (a condition characterized by chronic pain in the upper neck)

male:

Delirium (wild excitement)
Infusion related reaction
Pruritus (severe itching of the skin)
Pyrexia (fever)
Pruritus generalised (generalized itching)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dizziness
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased

What are the common drug interactions of Tramadol and Smoflipid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)

50-59:

Pneumonia
Arthralgia (joint pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Peripheral swelling
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Pain in extremity
Decreased appetite
Dehydration (dryness resulting from the removal of water)

60+:

Delirium (wild excitement)
Infusion related reaction
Pruritus (severe itching of the skin)
Pruritus generalised (generalized itching)
Dizziness
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Stomatitis (inflammation of mucous membrane of mouth): 7 people, 41.18%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 35.29%
Insomnia (sleeplessness): 5 people, 29.41%
Cancer Pain: 5 people, 29.41%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 23.53%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 17.65%
Sedation: 3 people, 17.65%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 11.76%
Anaemia (lack of blood): 2 people, 11.76%
Gastric Cancer (stomach cancer): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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