Tramadol and Tobi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Tobi (tobramycin). Common drug interactions include chronic obstructive pulmonary disease among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Tobi. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Tobi?

Tobi has active ingredients of tobramycin. eHealthMe is studying from 10,011 Tobi users. Check the latest studies of Tobi.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

64 people who take Tramadol and Tobi together, and have interactions are studied.

What are the common drug interactions of Tramadol and Tobi, by gender? *:

female:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)
Death
Fatigue (feeling of tiredness)
Headache (pain in head)
Lung disorder (lung disease)
Lung infection
Migraine (headache)

male:

Pneumonia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Attention deficit/hyperactivity disorder
Axonal neuropathy (dysfunction of axon nerves)
Blood immunoglobulin e increased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Chest pain
Chills (felling of cold)
Conjunctivitis (pink eye)
Death

What are the common drug interactions of Tramadol and Tobi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cough
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Pulmonary function test decreased
Rash generalised (rash on most of body parts)
Respiratory failure (inadequate gas exchange by the respiratory system)

20-29:

Malaise (a feeling of general discomfort or uneasiness)
Cystic fibrosis (disease of the secretary glands)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Dyspnoea (difficult or laboured respiration)
Lung disorder (lung disease)
Migraine (headache)
Lung infection
Lung transplant
Pain in extremity
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

30-39:

Ovarian cyst (fluid filled sac of the ovary)
Pneumonia
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Malaise (a feeling of general discomfort or uneasiness)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Chills (felling of cold)
Death
Dehydration (dryness resulting from the removal of water)

40-49:

Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Seasonal allergy (allergic condition due to certain season)
Skin ulcer
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Throat irritation
Vasculitis (inflammation of a blood vessel or blood vessels)
Wheezing (a high-pitched whistling sound made while you breath)
Chills (felling of cold)
Cough

50-59:

Cardiac disorder
Cardiac failure congestive
Chest pain
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Ill-defined disorder
Nausea (feeling of having an urge to vomit)
Pneumonia
Vomiting

60+:

Dyspnoea (difficult or laboured respiration)
Infection
Headache (pain in head)
Lung infection
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract)
Vomiting
Confusional state

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 23 people, 35.94%
Immunodeficiency Common Variable: 12 people, 18.75%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 10 people, 15.62%
Immune System Disorder: 6 people, 9.38%
Asthma: 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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