Tramadol and Trulance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Trulance (plecanatide). Common drug interactions include dysstasia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Trulance. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

95 people who take Tramadol and Trulance together, and have interactions are studied.

Tramadol and Trulance drug interactions.

What are the common drug interactions of Tramadol and Trulance, by gender? *:

female:

Dysstasia (difficulty in standing)
Erythema of eyelid (redness of the eyelid)
Constipation
Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Colitis ulcerative (inflammation of colon with ulcer)
Migraine (headache)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Diarrhoea
Pneumonia

male:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Drug resistance (reduction in effectiveness of a drug)
Dyspepsia (indigestion)
Dysstasia (difficulty in standing)
Fall
Fatigue (feeling of tiredness)
Hallucination, visual (seeing things that aren't there)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Impaired gastric emptying

What are the common drug interactions of Tramadol and Trulance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pneumonia
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

30-39:

Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)
Vision blurred
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Gastric disorder (disease of stomach)
Haematochezia (passage of stools containing blood)
Hypertension (high blood pressure)

40-49:

Eye discharge
Hypoaesthesia (reduced sense of touch or sensation)
Liver disorder (liver diseases)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sensory loss (senses loss)
Somnolence (a state of near-sleep, a strong desire for sleep)
Benign breast neoplasm (benign (non-cancerous) tumours of the breast)

50-59:

Diarrhoea
Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthma
Emotional distress
Fall
Nasopharyngitis (inflammation of the nasopharynx)
Optic neuritis (optic nerve inflammation)
Osteopenia (a condition where bone mineral density is lower than normal)
Defaecation urgency (a sudden compelling urge to defecate)

60+:

Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrophy (wasting away of a part of the body)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Dizziness
Drug ineffective
Hallucination, visual (seeing things that aren't there)
Hand fracture

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 20.00%
Constipation: 17 people, 17.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 10.53%
Drowsiness: 9 people, 9.47%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.42%
Asthma: 8 people, 8.42%
Depression: 7 people, 7.37%
Stress And Anxiety: 6 people, 6.32%
Irritable Bowel Syndrome: 6 people, 6.32%
Sleep Disorder: 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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