Tramadol and Whey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Whey (whey protein). Common drug interactions include diarrhoea among females and atrial flutter among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Whey. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Whey?

Whey has active ingredients of whey protein. It is often used in weight loss. eHealthMe is studying from 379 Whey users. Check the latest studies of Whey.



On Aug, 12, 2026

23 people who take Tramadol and Whey together, and have interactions are studied.

Tramadol and Whey drug interactions.

What are the common drug interactions of Tramadol and Whey, by gender? *:

female:

  1. Diarrhoea
  2. Constipation
  3. Exostosis (formation of new bone on the surface of a bone)
  4. Herpes zoster
  5. Insomnia (sleeplessness)
  6. Drug ineffective
  7. Vomiting
  8. Abdominal wall abscess (abdominal wall infection)
  9. Chronic kidney disease
  10. Dysgeusia (disorder of the sense of taste)

male:

  1. Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Inflammation
  4. Injection site erythema (redness at injection site)
  5. Injection site induration
  6. Injection site macule (alterations in skin colour at injection site)
  7. Injection site pain
  8. Injection site pruritus (severe itching at injection site)
  9. Injection site warmth
  10. Muscle spasms (muscle contraction)

What are the common drug interactions of Tramadol and Whey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Anxiety
  2. Hallucination, auditory (perceiving sounds without auditory stimulus)
  3. Hyperacusis (disorder in loudness perception)
  4. Insomnia (sleeplessness)
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Drug ineffective
  7. Inflammation
  8. Injection site erythema (redness at injection site)
  9. Injection site induration
  10. Injection site macule (alterations in skin colour at injection site)

40-49:

  1. Hallucination, auditory (perceiving sounds without auditory stimulus)
  2. Psychotic disorder

50-59:

  1. Chronic kidney disease
  2. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  3. Renal failure (kidney dysfunction)
  4. Sinusitis (inflammation of sinus)
  5. Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
  6. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  7. Diarrhoea
  8. Nasopharyngitis (inflammation of the nasopharynx)
  9. Cardiac disorder

60+:

  1. Abdominal wall abscess (abdominal wall infection)
  2. Dysgeusia (disorder of the sense of taste)
  3. Enterocutaneous fistula
  4. Rash
  5. Renal disorder (kidney disease)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 13 people, 56.52%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 13.04%
  3. Hypersensitivity: 3 people, 13.04%
  4. Constipation: 3 people, 13.04%
  5. Nausea And Vomiting: 2 people, 8.70%
  6. Metastases To Bone (cancer spreads to bone): 2 people, 8.70%
  7. Fever: 2 people, 8.70%
  8. Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 2 people, 8.70%
  9. Anaemia (lack of blood): 2 people, 8.70%
  10. Abdominal Pain: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tramadol and Whey:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Whey:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tramadol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Whey and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride and whey protein (the active ingredients of Tramadol and Whey, respectively), and Tramadol and Whey (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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