Trandate and Hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trandate (labetalol hydrochloride) and Hydrochlorothiazide (hydrochlorothiazide). Common drug interactions include arthralgia among females and haemorrhagic stroke among males.

The phase IV clinical study analyzes what interactions people have when they take Trandate and Hydrochlorothiazide. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Trandate?

Trandate has active ingredients of labetalol hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 1,735 Trandate users. Check the latest studies of Trandate.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,195 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

52 people who take Trandate and Hydrochlorothiazide together, and have interactions are studied.

Trandate and Hydrochlorothiazide drug interactions.

What are the common drug interactions of Trandate and Hydrochlorothiazide, by gender? *:

female:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blindness transient (sudden loss of vision)
Cardiac failure congestive
Chest pain
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

male:

Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Multiple injuries
Neoplasm malignant (cancer tumour)
Vomiting
Acute myocardial infarction (acute heart attack)
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug hypersensitivity
Drug ineffective
Hip fracture

What are the common drug interactions of Trandate and Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

Hyperhidrosis (abnormally increased sweating)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Injury
Insomnia (sleeplessness)
Liver transplant
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Necrosis (the death of body tissue)
Oedema peripheral (superficial swelling)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Diarrhoea
Chest discomfort
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain upper
Body temperature increased
Brain injury
Drug ineffective
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Diabetes: 9 people, 17.31%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 13.46%
Gait Disturbance: 6 people, 11.54%
Common Peroneal Nerve Dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes): 5 people, 9.62%
Colitis Microscopic (inflammation of colon with diarrhoea and abdominal cramps): 5 people, 9.62%
Type 2 Diabetes: 4 people, 7.69%
Depression: 4 people, 7.69%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 7.69%
Weight Decreased: 3 people, 5.77%
Hypotension (abnormally low blood pressure): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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