Tranexamic acid and Melphalan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tranexamic acid (tranexamic acid) and Melphalan (melphalan). Common drug interactions include hypertension among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Tranexamic acid and Melphalan. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Tranexamic acid?

Tranexamic acid has active ingredients of tranexamic acid. It is often used in heavy or prolong menstrual bleeding. eHealthMe is studying from 8,687 Tranexamic acid users. Check the latest studies of Tranexamic acid.

What is Melphalan?

Melphalan has active ingredients of melphalan. eHealthMe is studying from 20,052 Melphalan users. Check the latest studies of Melphalan.

On Jul, 26, 2026

33 people who take Tranexamic acid and Melphalan together, and have interactions are studied.

Tranexamic acid and Melphalan drug interactions.

What are the common drug interactions of Tranexamic Acid and Melphalan, by gender? *:

female:

Hypertension (high blood pressure)
Blood lactate dehydrogenase increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Lung disorder (lung disease)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Retinopathy (acute damage to the retina of the eye)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Respiratory rate increased (excess breathing rate/min)

male:

Febrile neutropenia (fever with reduced white blood cells)
Body temperature increased
Mucosal inflammation (infection of mucous membrane)
Pain
Rectal haemorrhage (bleeding from anus)
Venoocclusive liver disease (small veins in the liver are obstructed)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)

What are the common drug interactions of Tranexamic Acid and Melphalan, by age (0-1 to 60+)? *:

0-1:

Venoocclusive liver disease (small veins in the liver are obstructed)
Bone marrow failure
Febrile neutropenia (fever with reduced white blood cells)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Mucosal inflammation (infection of mucous membrane)
Pain
Rectal haemorrhage (bleeding from anus)

2-9:

Bk virus infection
Venoocclusive liver disease (small veins in the liver are obstructed)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Thrombocytopenia (decrease of platelets in blood)
Haemoglobin decreased
Haemorrhage (bleeding)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Brain stem haemorrhage (bleeding into structures of brain stem)
Disease progression

10-19:

Blood lactate dehydrogenase increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hypertension (high blood pressure)
Lung disorder (lung disease)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Retinopathy (acute damage to the retina of the eye)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

20-29:

n/a

30-39:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

40-49:

Body temperature increased
Diarrhoea
Escherichia infection (bacterial infection by escherichia coli)
Febrile neutropenia (fever with reduced white blood cells)
Frequent bowel movements
Hypotension (abnormally low blood pressure)
Leukopenia (less number of white blood cells in blood)
Pyrexia (fever)

50-59:

Bradycardia (abnormally slow heart action)
Chest discomfort
Respiratory rate increased (excess breathing rate/min)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

60+:

Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Rash
Respiratory rate increased (excess breathing rate/min)
Anxiety
Body temperature increased
Chills (felling of cold)
Hypersensitivity
Hypertension (high blood pressure)
Neck pain

What are the existing conditions these people have? *

Neuroblastoma (a cancer that forms in your nerve tissue): 15 people, 45.45%
Haemorrhage (bleeding): 12 people, 36.36%
Bone Marrow Conditioning Regimen: 11 people, 33.33%
Adverse Event: 5 people, 15.15%
Multiple Myeloma (cancer of the plasma cells): 3 people, 9.09%
Stress And Anxiety: 2 people, 6.06%
Pain: 2 people, 6.06%
Ovarian Cancer (cancer of ovary): 2 people, 6.06%
Leukaemia (blood or bone marrow cancer): 2 people, 6.06%
Insomnia (sleeplessness): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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