Tresiba and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tresiba (insulin degludec) and Fentanyl (fentanyl citrate). Common drug interactions include hypoglycaemia among females and atrioventricular block complete among males.

The phase IV clinical study analyzes what interactions people have when they take Tresiba and Fentanyl. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Tresiba?

Tresiba has active ingredients of insulin degludec. It is often used in type 1 diabetes. eHealthMe is studying from 20,677 Tresiba users. Check the latest studies of Tresiba.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Aug, 02, 2026

21 people who take Tresiba and Fentanyl together, and have interactions are studied.

What are the common drug interactions of Tresiba and Fentanyl, by gender? *:

female:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Agitation (state of anxiety or nervous excitement)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Drug ineffective
Hyperglycaemia (high blood sugar)
Pyrexia (fever)
Abscess limb (limb infection)
Aggression
Anal abscess
Cardiac failure

male:

Atrioventricular block complete (heart block complete)
Cardiogenic shock (inadequate circulation of blood)
Hyperglycaemia (high blood sugar)
Hypertension (high blood pressure)
Infection
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Renal impairment (severely reduced kidney function)
Respiratory depression (respiration has a rate below 12 breaths)

What are the common drug interactions of Tresiba and Fentanyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure decreased
Cardiac arrest
Heart rate decreased
Hypertension (high blood pressure)
Pyrexia (fever)
Respiratory depression (respiration has a rate below 12 breaths)
Sputum increased

50-59:

Atrioventricular block complete (heart block complete)
Cardiogenic shock (inadequate circulation of blood)
Abscess limb (limb infection)
Acidosis (build-up of carbon dioxide in the blood)
Anal abscess
Cellulitis (infection under the skin)
Chest pain
Genital abscess (build up of pus in genital)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperglycaemia (high blood sugar)

60+:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Hyperglycaemia (high blood sugar)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal impairment (severely reduced kidney function)
Weight decreased
Weight increased
Pyrexia (fever)
Aggression
Agitation (state of anxiety or nervous excitement)

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 23.81%
Nausea (feeling of having an urge to vomit): 5 people, 23.81%
Peripheral Arterial Occlusive Disease (reproducible ischemic muscle pain): 4 people, 19.05%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 19.05%
Hepatitis B: 4 people, 19.05%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 14.29%
Nausea And Vomiting: 3 people, 14.29%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 14.29%
Diabetes: 3 people, 14.29%
Depression: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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