Trexall and Azulfidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trexall (methotrexate sodium) and Azulfidine (sulfasalazine). Common drug interactions include fatigue among females and cyst among males.

The phase IV clinical study analyzes what interactions people have when they take Trexall and Azulfidine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Trexall?

Trexall has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 1,439 Trexall users. Check the latest studies of Trexall.

What is Azulfidine?

Azulfidine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 7,997 Azulfidine users. Check the latest studies of Azulfidine.

On Jul, 09, 2026

22 people who take Trexall and Azulfidine together, and have interactions are studied.

Trexall and Azulfidine drug interactions.

What are the common drug interactions of Trexall and Azulfidine, by gender? *:

female:

Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Infection
Pyrexia (fever)
Back pain
Chills (felling of cold)
Hypersensitivity
Injection site reaction
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)

male:

Cyst (a closed sac)
Arthralgia (joint pain)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Drug ineffective
Fatigue (feeling of tiredness)
Headache (pain in head)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Nerve root compression
Pain in jaw
Peripheral swelling

What are the common drug interactions of Trexall and Azulfidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Infection
Injection site pain
Injection site reaction
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Red blood cell sedimentation rate increased

40-49:

Back pain
Chills (felling of cold)
Fatigue (feeling of tiredness)
Infection
Myalgia (muscle pain)
Pyrexia (fever)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Injection site reaction
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pain in extremity
Sinusitis (inflammation of sinus)
Arthralgia (joint pain)
Drug ineffective
Erythema (redness of the skin)
Feeling hot
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site pruritus (severe itching at injection site)

60+:

Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Drug ineffective
Headache (pain in head)
Intervertebral disc protrusion (spinal disc protrusion)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Nerve root compression
Nodule (a growth of abnormal tissue)
Pain in jaw
Peripheral swelling

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 18.18%
Pain: 4 people, 18.18%
Muscle Spasms (muscle contraction): 4 people, 18.18%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 18.18%
High Blood Pressure: 4 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 18.18%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 4 people, 18.18%
Diabetes: 4 people, 18.18%
Back Pain: 4 people, 18.18%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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