Treximet and Botox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Botox (botulinum toxin type a). Common drug interactions include nephritis among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Botox. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

On Jul, 05, 2026

51 people who take Treximet and Botox together, and have interactions are studied.

What are the common drug interactions of Treximet and Botox, by gender? *:

female:

Nephritis (inflammation of the nephrons in the kidneys)
Nephrolithiasis (calculi in the kidneys)
Nerve compression
Oropharyngeal pain
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Drug ineffective
Neck pain

male:

Fatigue (feeling of tiredness)
Muscle atrophy (a decrease in the mass of the muscle)
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Impaired work ability
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Peroneal nerve palsy

What are the common drug interactions of Treximet and Botox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dysphagia (a condition in which swallowing is difficult or painful)
Headache (pain in head)
Bone loss
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Diarrhoea
Herpes zoster
Loose tooth
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle atrophy (a decrease in the mass of the muscle)
Neck pain

40-49:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Vomiting
Drug ineffective
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)
Disturbance in attention
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

50-59:

Drug ineffective
Fatigue (feeling of tiredness)
Headache (pain in head)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain
Road traffic accident

60+:

Neck mass (mass in neck)
Neck pain
Nodule (a growth of abnormal tissue)
Pain in extremity
Drug ineffective
Fatigue (feeling of tiredness)
Headache (pain in head)
Impaired work ability
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 35.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 9.80%
Muscle Spasms (muscle contraction): 3 people, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.88%
Headache (pain in head): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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