Tri-sprintec and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tri-sprintec (ethinyl estradiol; norgestimate) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include dry skin among females.

The phase IV clinical study analyzes what interactions people have when they take Tri-sprintec and Hydroxyzine. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Tri-sprintec?

Tri-sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 1,428 Tri-sprintec users. Check the latest studies of Tri-sprintec.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 10, 2026

30 people who take Tri-sprintec and Hydroxyzine together, and have interactions are studied.

Tri-sprintec and Hydroxyzine drug interactions.

What are the common drug interactions of Tri-Sprintec and Hydroxyzine, by gender? *:

female:

Dry skin
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Visual impairment
Abdominal discomfort
Cystitis interstitial (unknown cause characterized by bladder pain)
Depression
Drug hypersensitivity

male:

n/a

What are the common drug interactions of Tri-Sprintec and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Injection site reaction
Rash
Septic shock (shock due to blood infection)

20-29:

Dry skin
Eye pain
Eye swelling
Ocular hyperaemia (an abnormally large amount of blood in eye)
Conjunctivitis (pink eye)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Eye pruritus (eye itching)
Intraocular pressure increased
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Visual impairment

30-39:

Abdominal discomfort
Cystitis interstitial (unknown cause characterized by bladder pain)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haematuria (presence of blood in urine)
Headache (pain in head)
Pain
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

40-49:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Panniculitis (inflammation of the subcutaneous fat)
Vision blurred
Chronic kidney disease
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)

50-59:

Chronic kidney disease
Drug ineffective
Heart rate decreased
Heart rate increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

n/a

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 12 people, 40.00%
Itching: 5 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.33%
Multiple Allergies (allergy to multiple agents): 4 people, 13.33%
Asthma: 4 people, 13.33%
Depression: 3 people, 10.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.67%
Swelling: 2 people, 6.67%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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