Trilafon and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trilafon (perphenazine) and Pepcid (famotidine). Common drug interactions include chronic kidney disease among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Trilafon and Pepcid. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Trilafon?

Trilafon has active ingredients of perphenazine. It is often used in bipolar disorder. eHealthMe is studying from 1,448 Trilafon users. Check the latest studies of Trilafon.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 19, 2026

13 people who take Trilafon and Pepcid together, and have interactions are studied.

What are the common drug interactions of Trilafon and Pepcid, by gender? *:

female:

Chronic kidney disease
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Dehydration (dryness resulting from the removal of water)
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Blood cholesterol increased
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Optic neuropathy (optic nerve damage)
Papilloedema (optic disc swelling)
Tardive dyskinesia (a disorder that involves involuntary movements)
Diabetes mellitus inadequate control
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dyslipidaemia (abnormal amount of lipids)

What are the common drug interactions of Trilafon and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pharyngeal erythema (pharyngeal redness)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Throat irritation

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Angiopathy (generic term for a disease of the blood vessels)
Blood cholesterol increased
Depression
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Hyperglycaemia (high blood sugar)
Intermittent explosive disorder (behavioural disorder characterized by extreme expressions of anger)
Lung disorder (lung disease)

40-49:

Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Blood cholesterol increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dyslipidaemia (abnormal amount of lipids)
Hyperlipidaemia (presence of excess lipids in the blood)
Impaired gastric emptying

50-59:

Hypermagnesaemia (an electrolyte disturbance in which there is an abnormally elevated level of magnesium in the blood)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Neutrophilia
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Chronic kidney disease
Depression

60+:

Blood creatine phosphokinase increased
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 5 people, 38.46%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 23.08%
Pain: 3 people, 23.08%
Depression: 2 people, 15.38%
Sleep Disorder: 2 people, 15.38%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 15.38%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 15.38%
Affective Disorder (mental disorder): 2 people, 15.38%
Agitation (state of anxiety or nervous excitement): 2 people, 15.38%
Muscle Spasms (muscle contraction): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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