Trileptal and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Actos (pioglitazone hydrochloride). Common drug interactions include chronic obstructive pulmonary disease among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Actos. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

67 people who take Trileptal and Actos together, and have interactions are studied.

What are the common drug interactions of Trileptal and Actos, by gender? *:

female:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Dehydration (dryness resulting from the removal of water)
Depression
Hyperglycaemia (high blood sugar)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Weight increased
Abdominal pain lower
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chills (felling of cold)

male:

Neuropathy peripheral (surface nerve damage)
Dyspnoea (difficult or laboured respiration)
Weight decreased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bladder discomfort
Blood cholesterol increased
Blood triglycerides increased
Cardiac disorder

What are the common drug interactions of Trileptal and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased
Blood triglycerides increased
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Multiple drug overdose intentional
Suicide attempt
Suicidal ideation

30-39:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Pancreatitis chronic (chronic inflammation of pancreas)
Abdominal pain
Arthralgia (joint pain)
Avulsion fracture (bone fracture)

40-49:

Diabetes mellitus inadequate control
Blood cholesterol increased
Weight increased
Blood triglycerides increased
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)
Tardive dyskinesia (a disorder that involves involuntary movements)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Blood glucose increased
Chills (felling of cold)

50-59:

Palpitations (feelings or sensations that your heart is pounding or racing)
Pelvic mass
Pelvic pain
Postmenopausal haemorrhage (post-menopausal bleeding)
Pyrexia (fever)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vision blurred
Weight decreased
Weight increased
Abnormal dreams

60+:

Urinary tract infection
Anaemia (lack of blood)
Arthropathy
Asthenia (weakness)
Calculus bladder (bladder stone)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Chronic kidney disease
Coronary artery restenosis (recurrence of narrowing of artery)
Depression

What are the existing conditions these people have? *

Depression: 18 people, 26.87%
Stress And Anxiety: 13 people, 19.40%
Sleep Disorder: 9 people, 13.43%
Pain: 9 people, 13.43%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 8 people, 11.94%
Insomnia (sleeplessness): 8 people, 11.94%
Neuropathy Peripheral (surface nerve damage): 7 people, 10.45%
High Blood Cholesterol: 6 people, 8.96%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 7.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

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