Trileptal and Bumex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Bumex (bumetanide). Common drug interactions include fluid overload among females and blood chloride decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Bumex. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Bumex?

Bumex has active ingredients of bumetanide. It is often used in swelling. eHealthMe is studying from 9,210 Bumex users. Check the latest studies of Bumex.

On Jul, 13, 2026

24 people who take Trileptal and Bumex together, and have interactions are studied.

What are the common drug interactions of Trileptal and Bumex, by gender? *:

female:

Fluid overload (too much fluid in the blood)
Gallbladder disorder
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Generalised erythema (redness of the skin all over the body)
Jugular vein thrombosis (clot in jugular vein)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Ocular icterus (presence of jaundice seen in the sclera of the eye)

male:

Blood chloride decreased
Face injury
Headache (pain in head)
Inappropriate antidiuretic hormone secretion
Limb injury
Nausea (feeling of having an urge to vomit)
Photosensitivity reaction
Skin hyperpigmentation (disorders affect the colour of your skin)
Vomiting
Fall

What are the common drug interactions of Trileptal and Bumex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Back pain
Decreased appetite
Depression
Disturbance in attention
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Oedema peripheral (superficial swelling)
Speech disorder

30-39:

Chest pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspepsia (indigestion)
Hepatic enzyme increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Deformity (disfigurement)
Dry skin
Excoriation (to tear or wear off the skin of)
Generalised erythema (redness of the skin all over the body)

40-49:

Blood potassium decreased
Cataract (clouding of the lens inside the eye)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Electrolyte imbalance
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Jugular vein thrombosis (clot in jugular vein)
Pneumonia

50-59:

Asthenia (weakness)
Pruritus (severe itching of the skin)
Alanine aminotransferase increased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood glucose increased
Dyspnoea (difficult or laboured respiration)
Hepatitis a

60+:

Cardiac failure congestive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle)
Skin hyperpigmentation (disorders affect the colour of your skin)
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Anaemia (lack of blood)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Burning sensation

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 16.67%
High Blood Pressure: 3 people, 12.50%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 12.50%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.33%
Dyspnea (difficult or laboured breathing): 2 people, 8.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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