Trileptal and Fluconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Fluconazole (fluconazole). Common drug interactions include alanine aminotransferase increased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Fluconazole. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

100 people who take Trileptal and Fluconazole together, and have interactions are studied.

Trileptal and Fluconazole drug interactions.

What are the common drug interactions of Trileptal and Fluconazole, by gender? *:

female:

Alanine aminotransferase increased
Abdominal pain
Sinusitis (inflammation of sinus)
Pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dyspnoea (difficult or laboured respiration)

male:

Nausea (feeling of having an urge to vomit)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Fatigue (feeling of tiredness)
Gait disturbance
Haematemesis (vomiting of blood)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Lymphoedema (localized fluid retention and tissue swelling)
Oedema peripheral (superficial swelling)
Pain in extremity

What are the common drug interactions of Trileptal and Fluconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest discomfort
Pulmonary embolism (blockage of the main artery of the lung)
Abnormal behaviour

30-39:

Hepatic enzyme increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Anaemia (lack of blood)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Iron deficiency
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Arthralgia (joint pain)
Diarrhoea
Headache (pain in head)
Oropharyngeal pain
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Abdominal pain upper
Anaemia (lack of blood)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carbohydrate metabolism disorder (inability of carbohydrate metabolism)

50-59:

Facial pain
Haematocrit decreased
Haemoglobin decreased
Lymph node palpable
Mouth ulceration (mouth ulcers)
Nuclear magnetic resonance imaging brain
Periorbital oedema (swelling around the eyes)
Proctalgia (pain in the rectum)
Pruritus (severe itching of the skin)
Pyrexia (fever)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chronic kidney disease
Aphonia (inability to produce voice)
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthma
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))

What are the existing conditions these people have? *

Stress And Anxiety: 25 people, 25.00%
Depression: 25 people, 25.00%
Pain: 25 people, 25.00%
Nausea (feeling of having an urge to vomit): 16 people, 16.00%
Urinary Tract Infection: 14 people, 14.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 14 people, 14.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 14 people, 14.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 14.00%
Insomnia (sleeplessness): 14 people, 14.00%
Multiple Allergies (allergy to multiple agents): 13 people, 13.00%

* Approximation only. Some reports may have incomplete information.

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