Trileptal and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Hydroxyurea (hydroxyurea). Common drug interactions include aphasia among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Hydroxyurea. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

13 people who take Trileptal and Hydroxyurea together, and have interactions are studied.

Trileptal and Hydroxyurea drug interactions.

What are the common drug interactions of Trileptal and Hydroxyurea, by gender? *:

female:

Aphasia (damage to the parts of the brain that control language)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Disease progression
Muscular weakness (muscle weakness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaplastic astrocytoma (tumour of the glial (supportive) tissue of the brain)
Chest discomfort

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Pneumonia
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug level increased
Dysphagia (a condition in which swallowing is difficult or painful)
Epistaxis (bleed from the nose)
Facial bones fracture (bone fracture of face)
Fatigue (feeling of tiredness)

What are the common drug interactions of Trileptal and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chest discomfort
Eye colour change
Eye disorder
Eye pruritus (eye itching)
Eye swelling
Headache (pain in head)
Pain

20-29:

n/a

30-39:

n/a

40-49:

Aphasia (damage to the parts of the brain that control language)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disease progression
Muscular weakness (muscle weakness)
Anaplastic astrocytoma (tumour of the glial (supportive) tissue of the brain)
Hemiparesis (weakness on one side of the body)
Hemiplegia (paralysis of one side of the body)
Lethargy (tiredness)
Muscle twitching

50-59:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

60+:

n/a

What are the existing conditions these people have? *

Anaplastic Astrocytoma (tumour of the glial (supportive) tissue of the brain): 4 people, 30.77%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 3 people, 23.08%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 3 people, 23.08%
Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 1 person, 7.69%
Iron Overload: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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