Trileptal and Prempro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Prempro (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Prempro. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

On Aug, 07, 2026

38 people who take Trileptal and Prempro together, and have interactions are studied.

Trileptal and Prempro drug interactions.

What are the common drug interactions of Trileptal and Prempro, by gender? *:

female:

Anxiety
Alopecia (absence of hair from areas of the body)
Abdominal distension
Asthma
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Oedema peripheral (superficial swelling)

male:

n/a

What are the common drug interactions of Trileptal and Prempro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Influenza like illness
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Mycobacterium avium complex infection
Osteoporosis (bones weak and more likely to break)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Visual acuity reduced (reduced clearness of vision)
Vomiting

40-49:

Alopecia (absence of hair from areas of the body)
Depression
Hair colour changes
Hair disorder
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased
Drug detoxification
Dysarthria (speech disorder)
Enuresis (repeated inability to control urination)

50-59:

Type 2 diabetes mellitus
Upper respiratory tract infection
Urinary tract infection
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Diarrhoea
Disturbance in attention
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Impulse-control disorder
Loose stools
Muscle disorder (muscle disease)

60+:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Tardive dyskinesia (a disorder that involves involuntary movements)
Cold sweat
Constipation
Decreased appetite
Depressed level of consciousness
Depression
Dizziness
Drug abuser
Drug dependence

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 28.95%
Breast Cancer Female: 6 people, 15.79%
Immunodeficiency Common Variable: 4 people, 10.53%
Pain: 2 people, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.26%
Migraine (headache): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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