Trileptal and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Rapamune (sirolimus). Common drug interactions include basal cell carcinoma among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Rapamune. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jul, 23, 2026

28 people who take Trileptal and Rapamune together, and have interactions are studied.

Trileptal and Rapamune drug interactions.

What are the common drug interactions of Trileptal and Rapamune, by gender? *:

female:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Cardiac arrest
Dehydration (dryness resulting from the removal of water)
Fibroadenoma of breast (breast lump)
Hypoaesthesia (reduced sense of touch or sensation)
Intraductal papilloma of breast (tiny wart-like growth in breast tissue)
Ovarian cyst (fluid filled sac of the ovary)
Overdose
Partial seizures (seizures which affect only a part of the brain at onset)
Phyllodes tumour (breast tumour)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Therapeutic response unexpected
Headache (pain in head)
Heart rate increased
Hypertrichosis (hair growth on the body in an amount considered abnormal)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Kidney transplant rejection
Leukopenia (less number of white blood cells in blood)
Migraine (headache)

What are the common drug interactions of Trileptal and Rapamune, by age (0-1 to 60+)? *:

0-1:

Ear infection
Pneumonia viral
Respiratory distress (difficulty in breathing)
Malaise (a feeling of general discomfort or uneasiness)

2-9:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level below therapeutic
Electrolyte imbalance
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Erythema (redness of the skin)
General physical health deterioration (weak health status)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)
Heart rate increased

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Therapeutic response unexpected
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Gastric ulcer (stomach ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Kidney transplant rejection
Proteinuria (presence of protein in the urine)

20-29:

Drug effect decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

30-39:

Overdose
Partial seizures (seizures which affect only a part of the brain at onset)
Phyllodes tumour (breast tumour)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)
Thrombosis (formation of a blood clot inside a blood vessel)
Alopecia (absence of hair from areas of the body)
Drug withdrawal convulsions
Eye disorder
Speech disorder

40-49:

n/a

50-59:

Bone marrow transplant rejection
Drug level fluctuating
Drug ineffective

60+:

n/a

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 14 people, 50.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 7 people, 25.00%
Depression: 6 people, 21.43%
High Blood Pressure: 5 people, 17.86%
Heart Disease: 4 people, 14.29%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 14.29%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 14.29%
Thyroid Diseases: 4 people, 14.29%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 3 people, 10.71%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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