Trimethoprim and Fludara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimethoprim (trimethoprim) and Fludara (fludarabine phosphate). Common drug interactions include death among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Trimethoprim and Fludara. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Fludara?

Fludara has active ingredients of fludarabine phosphate. eHealthMe is studying from 46,686 Fludara users. Check the latest studies of Fludara.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

88 people who take Trimethoprim and Fludara together, and have interactions are studied.

Trimethoprim and Fludara drug interactions.

What are the common drug interactions of Trimethoprim and Fludara, by gender? *:

female:

Death
Drug ineffective
Bacillary angiomatosis (angiomatosis associated with bacteria of the bartonella genus)
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)
Facial palsy (paralysis of face nerve)
Fungal infection
Haemoglobin decreased

male:

Pyrexia (fever)
Neutropenia (an abnormally low number of neutrophils)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Body temperature increased
Bone neoplasm malignant (cancer of bone)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Device related infection
Dry eye (lack of adequate tears)

What are the common drug interactions of Trimethoprim and Fludara, by age (0-1 to 60+)? *:

0-1:

Pericardial effusion (fluid around the heart)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Autoimmune pancytopenia (abnormal deficiency in all blood cells by immune system deficiency)
Bacillus infection
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Graft versus host disease in liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver)
Lymphadenitis (inflammation or enlargement of a lymph node)

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Infusion related reaction
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Altered state of consciousness (altered state of mind)
Hypertension (high blood pressure)
Mycoplasma infection (bacterial infection)
Respiratory syncytial virus infection (viral disease of respiratory system)
Stomatitis (inflammation of mucous membrane of mouth)
Upper respiratory tract infection
Acute respiratory distress syndrome
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Bone marrow transplant rejection

20-29:

Colitis pseudomembranous (antibiotic-associated diarrhoea)
Eye disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hepatic function abnormal
Mucosal inflammation (infection of mucous membrane)
Skin disorder (skin disease)

30-39:

Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hepatic function abnormal
Mucosal inflammation (infection of mucous membrane)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia fungal
Renal impairment (severely reduced kidney function)
Skin disorder (skin disease)

40-49:

Device related infection
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Eye pain
Fatigue (feeling of tiredness)
Folliculitis (infection of hair root)
Gastrointestinal toxicity (damage to digestive tract by any substance)
Haemorrhage (bleeding)
Herpes zoster

50-59:

Haemoglobin decreased
Neutropenia (an abnormally low number of neutrophils)
Anaemia (lack of blood)
Disease complication
Dysphagia (a condition in which swallowing is difficult or painful)
Facial palsy (paralysis of face nerve)
Lacrimal disorder (disease of lacrimal duct)
Lung disorder (lung disease)
Meningitis pneumococcal (a bacterial infection of the membranes covering the brain and spinal cord (meninges))
Pneumococcal sepsis (pneumococcal sepsis is a serious medical condition where bacteria, specifically streptococcus pneumoniae)

60+:

Pyrexia (fever)
Cytomegalovirus infection
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Candida sepsis (candida in blood stream)
Cellulitis (infection under the skin)
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug ineffective
Febrile neutropenia (fever with reduced white blood cells)
Joint swelling

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 20 people, 22.73%
Bone Marrow Conditioning Regimen: 12 people, 13.64%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

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