Trimethoprim and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimethoprim (trimethoprim) and Melatonin (melatonin). Common drug interactions include pneumonia among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Trimethoprim and Melatonin. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Aug, 10, 2026

81 people who take Trimethoprim and Melatonin together, and have interactions are studied.

Trimethoprim and Melatonin drug interactions.

What are the common drug interactions of Trimethoprim and Melatonin, by gender? *:

female:

Pneumonia
Pyrexia (fever)
Skin cancer
Spinal fracture (fracture in one of vertebrae)
Therapeutic response unexpected
Wound infection
Diarrhoea
Hallucination, visual (seeing things that aren't there)
Muscular weakness (muscle weakness)
Oedema (fluid collection in tissue)

male:

Febrile neutropenia (fever with reduced white blood cells)
Abdominal distension
Renal failure (kidney dysfunction)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Weight gain poor
Anxiety
Emotional distress
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Pallor
Pneumonia fungal

What are the common drug interactions of Trimethoprim and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Device dislocation
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Weight gain poor
Hypertension (high blood pressure)
Lower respiratory tract infection
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

10-19:

Abdominal distension
Abdominal pain
Cough
Anxiety
Arthralgia (joint pain)
Bradycardia (abnormally slow heart action)
Catheter site haemorrhage (bleeding at catheter site)
Constipation
Depressed mood
Dyspnoea (difficult or laboured respiration)

20-29:

Platelet count decreased
Unresponsive to stimuli

30-39:

n/a

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)

50-59:

Depression
Emotional distress
Humerus fracture (injury to the upper arm bone)
Mobility decreased (ability to move is reduced)
Osteoporosis (bones weak and more likely to break)
Quality of life decreased
Renal injury (kidney injury)
Thoracic vertebral fracture
Upper limb fracture
Wrist fracture

60+:

Somnolence (a state of near-sleep, a strong desire for sleep)
Coma (state of unconsciousness lasting more than six hours)
Anaemia (lack of blood)
Back pain
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Animal scratch
Contusion (a type of hematoma of tissue in which capillaries)
Infusion related reaction

What are the existing conditions these people have? *

Pain: 33 people, 40.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.88%
Sleep Disorder: 6 people, 7.41%
High Blood Pressure: 6 people, 7.41%
Constipation: 6 people, 7.41%
Nausea (feeling of having an urge to vomit): 5 people, 6.17%
Infection: 5 people, 6.17%
Immunodeficiency Common Variable: 5 people, 6.17%
Dyspnea (difficult or laboured breathing): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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