Trimethoprim and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimethoprim (trimethoprim) and Premarin (estrogens, conjugated). Common drug interactions include pain among females.

The phase IV clinical study analyzes what interactions people have when they take Trimethoprim and Premarin. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 22, 2026

54 people who take Trimethoprim and Premarin together, and have interactions are studied.

Trimethoprim and Premarin drug interactions.

What are the common drug interactions of Trimethoprim and Premarin, by gender? *:

female:

Pain
Anxiety
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Vomiting
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

male:

n/a

What are the common drug interactions of Trimethoprim and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Blood calcium decreased
Blood creatine phosphokinase increased
Blood potassium decreased
Blood pressure systolic decreased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Chronic kidney disease
Diabetic complication
Drug ineffective
Ejection fraction decreased (systolic heart failure)

50-59:

Abdominal pain
Back pain
Blindness unilateral
Blood glucose increased
Cataract (clouding of the lens inside the eye)
Corneal abrasion (loss of the surface of cornea)
Cough
Diarrhoea
Dizziness
Dry eye (lack of adequate tears)

60+:

Anxiety
Cardiac failure congestive
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vaginal discharge
Vaginal disorder
Vaginal infection
Multiple injuries
Blood cholesterol increased

What are the existing conditions these people have? *

Pain: 6 people, 11.11%
Heart Rate Irregular: 5 people, 9.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.26%
Insomnia (sleeplessness): 4 people, 7.41%
Stress And Anxiety: 3 people, 5.56%
Immunodeficiency Common Variable: 3 people, 5.56%
High Blood Pressure: 3 people, 5.56%
Depression: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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