Trimethoprim and Pyrimethamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimethoprim (trimethoprim) and Pyrimethamine (pyrimethamine). Common drug interactions include hyperglycaemia among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Trimethoprim and Pyrimethamine. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Pyrimethamine?

Pyrimethamine has active ingredients of pyrimethamine. eHealthMe is studying from 1,514 Pyrimethamine users. Check the latest studies of Pyrimethamine.

On Jul, 05, 2026

19 people who take Trimethoprim and Pyrimethamine together, and have interactions are studied.

Trimethoprim and Pyrimethamine drug interactions.

What are the common drug interactions of Trimethoprim and Pyrimethamine, by gender? *:

female:

Hyperglycaemia (high blood sugar)

male:

Hypotension (abnormally low blood pressure)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Muscular weakness (muscle weakness)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Complex partial seizures (epileptic seizure)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Pupils unequal
Death
Paraparesis (partial paralysis of the lower limbs)

What are the common drug interactions of Trimethoprim and Pyrimethamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiolipin antibody positive
Eye infection toxoplasmal (a germ called toxoplasma can cause infection within the eye)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hepatitis (inflammation of the liver)
Interstitial lung disease
Myositis (inflammation of the muscles)
Pericarditis (inflammation of the pericardium)
Proteinuria (presence of protein in the urine)

30-39:

Agitation (state of anxiety or nervous excitement)
Blood creatine phosphokinase increased
Blood magnesium decreased
Blood potassium decreased
Dyskinesia (abnormality or impairment of voluntary movement)
Ataxia (loss of full control of bodily movements)
Headache (pain in head)
Muscular weakness (muscle weakness)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

40-49:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Hyperglycaemia (high blood sugar)
Mouth ulceration (mouth ulcers)
Rash erythematous (redness of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Hiv Infection: 16 people, 84.21%
Agitation (state of anxiety or nervous excitement): 15 people, 78.95%
Toxoplasmosis (a parasitic disease caused by the protozoan toxoplasma gondii): 14 people, 73.68%
Uveitis (inflammation of the uvea): 1 person, 5.26%
Eye Infection Toxoplasmal (a germ called toxoplasma can cause infection within the eye): 1 person, 5.26%
Discomfort: 1 person, 5.26%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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