Trimox and Metronidazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimox (amoxicillin) and Metronidazole (metronidazole). Common drug interactions include tubulointerstitial nephritis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Trimox and Metronidazole. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Trimox?

Trimox has active ingredients of amoxicillin. eHealthMe is studying from 932 Trimox users. Check the latest studies of Trimox.

What is Metronidazole?

Metronidazole has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 59,578 Metronidazole users. Check the latest studies of Metronidazole.

On Jul, 12, 2026

46 people who take Trimox and Metronidazole together, and have interactions are studied.

Trimox and Metronidazole drug interactions.

What are the common drug interactions of Trimox and Metronidazole, by gender? *:

female:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cough
Abdominal pain upper
Constipation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Injury
Mitral valve incompetence (inefficient heart valve)
Nephrogenic anaemia (anaemia due to kidney disease)
Pulmonary valve incompetence
Renal impairment (severely reduced kidney function)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Hypotension (abnormally low blood pressure)
Multiple injuries
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Trimox and Metronidazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Chronic kidney disease
Hypertension (high blood pressure)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Accident
Drug dependence
Injury

40-49:

Renal failure (kidney dysfunction)
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder
Emotional distress
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Foot fracture
Injury

50-59:

Back pain
Balance disorder
Burning sensation
Cough
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Intervertebral disc degeneration (spinal disc degeneration)
Muscular weakness (muscle weakness)
Nephropathy (damage to or disease of a kidney)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Constipation
Cough
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Multiple injuries
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 28 people, 60.87%
Pain: 20 people, 43.48%
Depression: 19 people, 41.30%
Infection: 17 people, 36.96%
High Blood Pressure: 15 people, 32.61%
Stress And Anxiety: 12 people, 26.09%
Asthma: 11 people, 23.91%
Nausea (feeling of having an urge to vomit): 11 people, 23.91%
Cardiac Disorder: 10 people, 21.74%
Hypersensitivity: 10 people, 21.74%

* Approximation only. Some reports may have incomplete information.

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