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Trimox and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimox (amoxicillin) and Singulair (montelukast sodium). Common drug interactions include arthralgia among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Trimox and Singulair. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Trimox?

Trimox has active ingredients of amoxicillin. eHealthMe is studying from 932 Trimox users. Check the latest studies of Trimox.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

On Jul, 11, 2026

30 people who take Trimox and Singulair together, and have interactions are studied.

Trimox and Singulair drug interactions.

What are the common drug interactions of Trimox and Singulair, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
  3. Fatigue (feeling of tiredness)
  4. Haematocrit decreased
  5. Haemoglobin decreased
  6. Headache (pain in head)
  7. Myalgia (muscle pain)
  8. Nephrogenic anaemia (anaemia due to kidney disease)
  9. Papillary thyroid cancer
  10. Renal injury (kidney injury)

male:

  1. Cardiac arrest
  2. Cold sweat
  3. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  4. Arthropathy
  5. Asthenia (weakness)
  6. Atelectasis (partial or complete collapse of the lung)
  7. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  8. Atrioventricular block complete (heart block complete)
  9. Avulsion fracture (bone fracture)
  10. Back pain

What are the common drug interactions of Trimox and Singulair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Cold sweat
  2. Tremor (trembling or shaking movements in one or more parts of your body)
  3. Panic attack
  4. Panic reaction

10-19:

n/a

20-29:

  1. Bronchial hyperreactivity
  2. Cellulitis (infection under the skin)
  3. Dyspepsia (indigestion)
  4. Emotional disorder
  5. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Injection site erythema (redness at injection site)
  8. Injection site induration
  9. Injection site mass
  10. Injection site pain

30-39:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)
  4. Renal tubular necrosis (death of kidney tubules)
  5. Death

40-49:

  1. Antinuclear factor positive
  2. Chronic kidney disease
  3. Erythrocyte sedimentation rate increased
  4. Fatigue (feeling of tiredness)
  5. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  6. Haematocrit decreased
  7. Haemoglobin decreased
  8. Headache (pain in head)
  9. Hepatitis (inflammation of the liver)
  10. Hepatitis b antibody positive

50-59:

  1. Abdominal pain upper
  2. Activities of daily living impaired
  3. Alanine aminotransferase increased
  4. Arthralgia (joint pain)
  5. Aspartate aminotransferase increased
  6. Asthenia (weakness)
  7. Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
  8. Blood alkaline phosphatase increased
  9. Blood cholesterol increased
  10. Blood creatine decreased

60+:

  1. Chronic kidney disease
  2. Cardiac arrest
  3. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  4. Arthralgia (joint pain)
  5. Arthropathy
  6. Asthenia (weakness)
  7. Atelectasis (partial or complete collapse of the lung)
  8. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  9. Atrioventricular block complete (heart block complete)
  10. Avulsion fracture (bone fracture)

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 50.00%
  2. Pain: 9 people, 30.00%
  3. Nausea (feeling of having an urge to vomit): 8 people, 26.67%
  4. Cardiac Disorder: 6 people, 20.00%
  5. Depression: 6 people, 20.00%
  6. Gastric Ulcer (stomach ulcer): 6 people, 20.00%
  7. Stress And Anxiety: 6 people, 20.00%
  8. Diabetes: 6 people, 20.00%
  9. Muscle Aches (muscle pain): 5 people, 16.67%
  10. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Trimox and Singulair?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Trimox and Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Trimox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trimox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Singulair and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin and montelukast sodium (the active ingredients of Trimox and Singulair, respectively), and Trimox and Singulair (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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