Trintellix and Digoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Digoxin (digoxin). Common drug interactions include abdominal discomfort among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Digoxin. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

On Jul, 13, 2026

18 people who take Trintellix and Digoxin together, and have interactions are studied.

Trintellix and Digoxin drug interactions.

What are the common drug interactions of Trintellix and Digoxin, by gender? *:

female:

Abdominal discomfort
Dizziness
Fall
Flushing (the warm, red condition of human skin)
Hypertension (high blood pressure)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pain
Pruritus generalised (generalized itching)
Pyrexia (fever)

male:

Abdominal discomfort
Back pain
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Pain in jaw
Palpitations (feelings or sensations that your heart is pounding or racing)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Vomiting
Diarrhoea

What are the common drug interactions of Trintellix and Digoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Back pain
Diarrhoea
Fall
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Hypervolaemia (abnormally increased volume of blood)
Infusion site pain
Loss of consciousness

30-39:

n/a

40-49:

Asthenia (weakness)
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Dizziness
Fall
Fatigue (feeling of tiredness)
Femur fracture
Haemoglobin decreased
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)

50-59:

n/a

60+:

Hypertension (high blood pressure)
Pruritus generalised (generalized itching)
Fall
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Hypoacusis (loss of hearing)
Migraine (headache)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 38.89%
Urinary Tract Infection: 1 person, 5.56%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.56%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 5.56%
Pyoderma Gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance): 1 person, 5.56%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 1 person, 5.56%
Pain: 1 person, 5.56%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 5.56%
Neuralgia (pain in one or more nerves): 1 person, 5.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Trintellix and Digoxin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously