Trintellix and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Pepcid (famotidine). Common drug interactions include restless legs syndrome among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Pepcid. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 18, 2026

78 people who take Trintellix and Pepcid together, and have interactions are studied.

Trintellix and Pepcid drug interactions.

What are the common drug interactions of Trintellix and Pepcid, by gender? *:

female:

Restless legs syndrome (a powerful urge to move your legs)
Shoulder operation
Swelling
Therapeutic response unexpected
Transaminases increased
Upper limb fracture
Urinary tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight fluctuation
Wrist fracture

male:

Arthralgia (joint pain)
Decreased appetite
Visual impairment
Agitation (state of anxiety or nervous excitement)
Anger
Back pain
Blood cholesterol increased
Body height decreased
Confusional state
Death

What are the common drug interactions of Trintellix and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Injection site reaction

20-29:

Anxiety disorder
Body dysmorphic disorder (type of mental illness)
Constipation
Cough
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Ear pain

30-39:

Pruritus (severe itching of the skin)
Suicidal ideation
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug clearance increased
Dry eye (lack of adequate tears)
Fatigue (feeling of tiredness)
Infected cyst
Spondylitis (an inflammation of the vertebra with spinal cord involvement)

40-49:

Adverse event
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Back pain
Bacterial infection
Balance disorder

50-59:

Nausea (feeling of having an urge to vomit)
Anxiety
Vomiting
Blood alkaline phosphatase increased
Breast cancer
Muscle spasms (muscle contraction)
Panic attack
Transaminases increased
Blood pressure increased
Bradycardia (abnormally slow heart action)

60+:

Peripheral swelling
Cardiac failure
Death
Foot deformity (functional disability of foot)
Hypersensitivity
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Restless legs syndrome (a powerful urge to move your legs)
Stress
Cardiomyopathy (weakening of the heart muscle)
Drug ineffective

What are the existing conditions these people have? *

Pain: 18 people, 23.08%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 15.38%
Stress And Anxiety: 11 people, 14.10%
Immunodeficiency Common Variable: 10 people, 12.82%
Sleep Disorder: 8 people, 10.26%
Drowsiness: 8 people, 10.26%
High Blood Cholesterol: 7 people, 8.97%
Hypersensitivity: 6 people, 7.69%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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