Trintellix and Progesterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Progesterone (progesterone). Common drug interactions include gait disturbance among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Progesterone. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,022 Progesterone users. Check the latest studies of Progesterone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

76 people who take Trintellix and Progesterone together, and have interactions are studied.

Trintellix and Progesterone drug interactions.

What are the common drug interactions of Trintellix and Progesterone, by gender? *:

female:

Gait disturbance
Insomnia (sleeplessness)
Oropharyngeal pain
Suicidal ideation
Hyperthyroidism (over activity of the thyroid gland)
Back pain
Dehydration (dryness resulting from the removal of water)
Fall
Infusion site discomfort
Memory impairment

male:

Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the common drug interactions of Trintellix and Progesterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Drug diversion
Psychotic disorder
Fatigue (feeling of tiredness)
Hypersensitivity
Nausea (feeling of having an urge to vomit)
Suicidal ideation

30-39:

Abdominal pain upper
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Chest pain
Decreased appetite
Drug ineffective
Dysmenorrhoea (painful menstruation)
Eye disorder
Eye swelling

40-49:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Bacterial infection
Balance disorder
Burning sensation
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cataract (clouding of the lens inside the eye)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state

50-59:

Abdominal distension
Arthralgia (joint pain)
Dehydration (dryness resulting from the removal of water)
Erythema (redness of the skin)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fatigue (feeling of tiredness)
Feeling hot
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Infectious mononucleosis (infection usually caused by the epstein-barr virus)

60+:

Insomnia (sleeplessness)
Restlessness (not able to rest)
Blood creatinine decreased
Blood glucose increased
Blood pressure decreased
Blood pressure increased
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Confusional state
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Diarrhoea

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 34 people, 44.74%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 31.58%
Immunodeficiency Common Variable: 6 people, 7.89%
Drowsiness: 5 people, 6.58%

* Approximation only. Some reports may have incomplete information.

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