Trintellix and Zyprexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Zyprexa (olanzapine). Common drug interactions include mental disorder among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Zyprexa. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

On Jul, 15, 2026

81 people who take Trintellix and Zyprexa together, and have interactions are studied.

Trintellix and Zyprexa drug interactions.

What are the common drug interactions of Trintellix and Zyprexa, by gender? *:

female:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oral discomfort (pain or irritation in mouth)
Pain
Synovial cyst (cyst of joint filled with synovial fluid)
Toothache (tooth pain)
Ulcer haemorrhage (bleeding ulcer)
Vitamin d decreased
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

male:

Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Energy increased
Erectile dysfunction
Food poisoning (poison in food)
Hypersomnia (excessive daytime sleepiness (eds))
Inflammation
Joint injury
Loss of consciousness
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)

What are the common drug interactions of Trintellix and Zyprexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal behaviour
Disease recurrence
Suicidal ideation
Therapeutic response unexpected
Weight increased

20-29:

Dyskinesia (abnormality or impairment of voluntary movement)
Emotional distress
Energy increased
Erectile dysfunction
Fatigue (feeling of tiredness)
Food poisoning (poison in food)
Hypersomnia (excessive daytime sleepiness (eds))
Inflammation
Joint injury
Loss of consciousness

30-39:

Fatigue (feeling of tiredness)
Infected cyst
Sedation
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Cellulitis (infection under the skin)
Pruritus (severe itching of the skin)
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Weight increased
Depressed mood
Fatigue (feeling of tiredness)
Hospitalisation
Infection
Muscle spasms (muscle contraction)

50-59:

Rash
Road traffic accident
Neuralgia (pain in one or more nerves)
Vertebral foraminal stenosis (narrowing of the intervertebral foramen)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Haematuria (presence of blood in urine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Arthralgia (joint pain)
Cough
Crying

60+:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Brain neoplasm (tumour of brain)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fall
Hip fracture
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 32.10%
Stress And Anxiety: 14 people, 17.28%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 16.05%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 7.41%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 6.17%
Insomnia (sleeplessness): 5 people, 6.17%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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