Trulance and Ajovy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulance (plecanatide) and Ajovy (fremanezumab-vfrm). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Trulance and Ajovy. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

What is Ajovy?

Ajovy has active ingredients of fremanezumab-vfrm. eHealthMe is studying from 8,834 Ajovy users. Check the latest studies of Ajovy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

16 people who take Trulance and Ajovy together, and have interactions are studied.

What are the common drug interactions of Trulance and Ajovy, by gender? *:

female:

Headache (pain in head)
Sinusitis (inflammation of sinus)
Emergency care
General physical condition
Insomnia (sleeplessness)
Migraine (headache)
Nervousness
Oropharyngeal pain
Panic attack
Pruritus (severe itching of the skin)

male:

n/a

What are the common drug interactions of Trulance and Ajovy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)

30-39:

n/a

40-49:

Nervousness
Panic attack
Pruritus (severe itching of the skin)
Rash macular (small, flat red spots)
Scar
Sinusitis (inflammation of sinus)
Suicidal ideation
Weight increased
Abdominal pain upper
Blood cholesterol increased

50-59:

Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

60+:

Headache (pain in head)

What are the existing conditions these people have? *

Migraine (headache): 3 people, 18.75%
Immunology Test Abnormal: 3 people, 18.75%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 3 people, 18.75%
Stress And Anxiety: 2 people, 12.50%
Sleep Disorder: 2 people, 12.50%
Nerve Injury: 2 people, 12.50%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 12.50%
Itching: 2 people, 12.50%
Impaired Gastric Emptying: 2 people, 12.50%
Immunodeficiency Common Variable: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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