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Truvada and Apixaban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Truvada (emtricitabine; tenofovir disoproxil fumarate) and Apixaban (apixaban). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Truvada and Apixaban. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

What is Apixaban?

Apixaban has active ingredients of apixaban. It is often used in blood clots. eHealthMe is studying from 60,351 Apixaban users. Check the latest studies of Apixaban.

On Jul, 20, 2026

13 people who take Truvada and Apixaban together, and have interactions are studied.

Truvada and Apixaban drug interactions.

What are the common drug interactions of Truvada and Apixaban, by gender? *:

female:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Depression
  4. Emotional distress
  5. Pain
  6. Chronic kidney disease
  7. Renal impairment (severely reduced kidney function)
  8. Thrombosis (formation of a blood clot inside a blood vessel)
  9. Renal failure (kidney dysfunction)
  10. Crying

male:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Depression
  4. Fatigue (feeling of tiredness)
  5. Libido decreased (loss of interest in sex)
  6. Nausea (feeling of having an urge to vomit)
  7. Renal failure (kidney dysfunction)
  8. Bone density decreased
  9. Anaemia (lack of blood)
  10. Leukopenia (less number of white blood cells in blood)

What are the common drug interactions of Truvada and Apixaban, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Chronic kidney disease
  4. Crying
  5. Depression
  6. Emotional distress
  7. Pain
  8. Renal atrophy (wasting of kidney)
  9. Renal impairment (severely reduced kidney function)
  10. Restlessness (not able to rest)

30-39:

  1. Chronic kidney disease
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Anxiety
  4. Depression
  5. Emotional distress
  6. Pain
  7. Renal failure (kidney dysfunction)
  8. Asthenia (weakness)
  9. Blood creatinine increased
  10. Device related infection

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Chronic kidney disease
  5. Emotional distress
  6. Pain
  7. Renal impairment (severely reduced kidney function)

50-59:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Pain
  5. Asthenia (weakness)
  6. Chronic kidney disease
  7. Fatigue (feeling of tiredness)
  8. Libido decreased (loss of interest in sex)
  9. Nausea (feeling of having an urge to vomit)
  10. Renal impairment (severely reduced kidney function)

60+:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Nephropathy (damage to or disease of a kidney)
  5. Osteoporosis (bones weak and more likely to break)
  6. Pain
  7. Renal failure (kidney dysfunction)
  8. Renal impairment (severely reduced kidney function)
  9. Spinal osteoarthritis (joint cartilage loss in spine)

What are the existing conditions these people have? *

  1. Viral Infection: 3 people, 23.08%
  2. Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 3 people, 23.08%
  3. Bacterial Infection: 3 people, 23.08%
  4. Cough: 3 people, 23.08%
  5. Depression: 3 people, 23.08%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
  7. Hypersensitivity: 3 people, 23.08%
  8. High Blood Pressure: 3 people, 23.08%
  9. Pain: 3 people, 23.08%
  10. Nausea (feeling of having an urge to vomit): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

Do you take Truvada and Apixaban?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Truvada and Apixaban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Truvada:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Apixaban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Truvada and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Apixaban and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on emtricitabine; tenofovir disoproxil fumarate and apixaban (the active ingredients of Truvada and Apixaban, respectively), and Truvada and Apixaban (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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