Truvada and Tracleer drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Truvada (emtricitabine; tenofovir disoproxil fumarate) and Tracleer (bosentan). Common drug interactions include headache among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Truvada and Tracleer. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

On Jul, 08, 2026

26 people who take Truvada and Tracleer together, and have interactions are studied.

What are the common drug interactions of Truvada and Tracleer, by gender? *:

female:

Headache (pain in head)
Face oedema (swelling of face)
Lacrimation increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Diarrhoea
Hypotension (abnormally low blood pressure)
Dizziness
Nausea (feeling of having an urge to vomit)
Portopulmonary hypertension (coexistence of portal and pulmonary hypertension)

male:

Fall
Balance disorder
Blood creatine phosphokinase increased
Faeces pale
Hypotension (abnormally low blood pressure)
Psychiatric symptom
Suicide attempt
Vomiting
Dizziness
Dizziness postural

What are the common drug interactions of Truvada and Tracleer, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abortion induced (medically referred abortion)
Cerebral haemorrhage (bleeding within the brain)
Chest pain
Diarrhoea
Diplopia (double vision)
Drug exposure during pregnancy
Epistaxis (bleed from the nose)
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

40-49:

Headache (pain in head)
Face oedema (swelling of face)
Lacrimation increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Portopulmonary hypertension (coexistence of portal and pulmonary hypertension)
Aphthous stomatitis (mouth ulcer)
Back pain
Cough
Dehydration (dryness resulting from the removal of water)

50-59:

Confusional state
Fall
Nausea (feeling of having an urge to vomit)
Diarrhoea
Drug level increased
Asthenia (weakness)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Vertigo
Alveolar osteitis (complication of wound healing following extraction of a tooth)

60+:

Dizziness postural
Fall
Fluid overload (too much fluid in the blood)
Memory impairment
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pleural effusion (water on the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory disorder (respiratory disease)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Hepatitis C: 7 people, 26.92%
Portopulmonary Hypertension (coexistence of portal and pulmonary hypertension): 4 people, 15.38%
Diarrhea: 3 people, 11.54%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 7.69%
Hiv Test Positive: 2 people, 7.69%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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