Tykerb and Doxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tykerb (lapatinib ditosylate) and Doxil (doxorubicin hydrochloride). Common drug interactions include metastases to central nervous system among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Tykerb and Doxil. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

What is Doxil?

Doxil has active ingredients of doxorubicin hydrochloride. It is often used in ovarian cancer. eHealthMe is studying from 10,479 Doxil users. Check the latest studies of Doxil.

On Aug, 02, 2026

29 people who take Tykerb and Doxil together, and have interactions are studied.

What are the common drug interactions of Tykerb and Doxil, by gender? *:

female:

Metastases to central nervous system (cancer spreads to central nervous system)
Pain
Abdominal pain
Hypoaesthesia (reduced sense of touch or sensation)
Metastases to liver (cancer spreads to liver)
Chest pain
Fatigue (feeling of tiredness)
Metastases to lymph nodes (cancer spreads to lymph node)
Pleural effusion (water on the lungs)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abdominal pain
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Blood glucose decreased
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)

What are the common drug interactions of Tykerb and Doxil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Constipation
Diarrhoea
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Pain
Rash
Upper respiratory tract infection

50-59:

Cardiomegaly (increased size of heart than normal)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dermal cyst
Disability
Dizziness
Dyspnoea (difficult or laboured respiration)
Escherichia sepsis (bacterial infection by escherichia coli)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Metastases to lymph nodes (cancer spreads to lymph node)
Pleural effusion (water on the lungs)
Skin fissures (a crack in the skin)
Streptococcal sepsis (whole body inflammation by streptococcal)
Nail bed inflammation (infection of nail bed)
Nausea (feeling of having an urge to vomit)
Back pain
Metastases to central nervous system (cancer spreads to central nervous system)
Vomiting
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 10 people, 34.48%
Dyspnea (difficult or laboured breathing): 5 people, 17.24%
Cough: 5 people, 17.24%
Breast Cancer Metastatic: 5 people, 17.24%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 4 people, 13.79%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 13.79%
Skin Fissures (a crack in the skin): 3 people, 10.34%
Paronychia (infection in the tissues adjacent to a nail on a finger or toe): 3 people, 10.34%
Streptococcal Sepsis (whole body inflammation by streptococcal): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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