Tykerb and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tykerb (lapatinib ditosylate) and Pepcid (famotidine). Common drug interactions include anaemia among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Tykerb and Pepcid. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 28, 2026

52 people who take Tykerb and Pepcid together, and have interactions are studied.

What are the common drug interactions of Tykerb and Pepcid, by gender? *:

female:

Anaemia (lack of blood)
Anxiety
Atelectasis (partial or complete collapse of the lung)
Bone pain
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Hepatic lesion
Injury
Metastases to bone (cancer spreads to bone)
Metastases to lymph nodes (cancer spreads to lymph node)

male:

Nausea (feeling of having an urge to vomit)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Bone pain
Cardiac tamponade (fluid accumulates in heart covering)
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Cerebral cyst (fluid filled tumour of brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Clavicle fracture

What are the common drug interactions of Tykerb and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain lower
Abortion spontaneous (naturally occurring miscarriage)
Breast pain
Cough
Diarrhoea
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Epistaxis (bleed from the nose)
Human chorionic gonadotropin decreased
Ingrowing nail

40-49:

Asthenia (weakness)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Erythema (redness of the skin)
Hepatic failure (liver failure)
Nausea (feeling of having an urge to vomit)
Necrosis (the death of body tissue)
Skin discolouration (change of skin colour)
Skin disorder (skin disease)

50-59:

Oedema peripheral (superficial swelling)
Vomiting
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Bone pain

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Aortic valve incompetence
Arachnoid cyst
Arthropathy
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 7 people, 13.46%

* Approximation only. Some reports may have incomplete information.

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