Tylenol w/ codeine no. 3 and Acyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate) and Acyclovir (acyclovir). Common drug interactions include musculoskeletal stiffness among females and ascites among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine no. 3 and Acyclovir. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

43 people who take Tylenol w/ codeine no. 3 and Acyclovir together, and have interactions are studied.

Tylenol w/ codeine no. 3 and Acyclovir drug interactions.

What are the common drug interactions of Tylenol W/ Codeine No. 3 and Acyclovir, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain of skin
Scar
Skin exfoliation (removal of the oldest dead skin cells)
Skin fibrosis (fibrous tissue formation on skin)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)

male:

Ascites (accumulation of fluid in the abdominal cavity)
Venoocclusive liver disease (small veins in the liver are obstructed)
Haemoglobin decreased
Melaena (the passage of black, tarry stools)
Multiple myeloma (cancer of the plasma cells)
Neutropenia (an abnormally low number of neutrophils)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Red blood cell count decreased
Weight increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Tylenol W/ Codeine No. 3 and Acyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood creatinine increased
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)

30-39:

Nausea (feeling of having an urge to vomit)
Vomiting
Ammonia increased
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Hypotension (abnormally low blood pressure)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Oesophageal reflux (moving the food downwards)
Oral candidiasis (fungal infection of mouth)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal distension

40-49:

Hemiparesis (weakness on one side of the body)
Hepatic enzyme increased
Hepatitis a antibody positive
Hepatitis acute
Hepatitis c rna positive
Hepatitis viral
Hepatomegaly (abnormal enlargement of the liver)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hodgkin's disease (cancer originating from white blood cells)
Iatrogenic injury (iatrogenic injury is a form of medical error)

50-59:

Cellulitis (infection under the skin)
Deformity (disfigurement)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

60+:

Asthenia (weakness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Red blood cell count decreased
Upper respiratory tract infection
Urinary tract infection
White blood cell count decreased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Confusional state

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 16 people, 37.21%
Stress And Anxiety: 13 people, 30.23%
Depression: 13 people, 30.23%
Itching: 12 people, 27.91%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 12 people, 27.91%
Nuclear Magnetic Resonance Imaging Brain: 12 people, 27.91%
High Blood Cholesterol: 12 people, 27.91%
Herpes Zoster: 12 people, 27.91%
Device Related Infection: 12 people, 27.91%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 7 people, 16.28%

* Approximation only. Some reports may have incomplete information.

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