Tylenol w/ codeine no. 3 and Fluconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate) and Fluconazole (fluconazole). Common drug interactions include carotid artery stenosis among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine no. 3 and Fluconazole. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

On Jul, 08, 2026

53 people who take Tylenol w/ codeine no. 3 and Fluconazole together, and have interactions are studied.

Tylenol w/ codeine no. 3 and Fluconazole drug interactions.

What are the common drug interactions of Tylenol W/ Codeine No. 3 and Fluconazole, by gender? *:

female:

Carotid artery stenosis (narrowing of carotid artery)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Diarrhoea
Dizziness
Failure to thrive (inadequate weight gain and physical growth in children)
Fatigue (feeling of tiredness)

male:

Pyrexia (fever)
Liver disorder (liver diseases)
Cerebellar ischaemia (lack of blood supply to cerebeller)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)

What are the common drug interactions of Tylenol W/ Codeine No. 3 and Fluconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
Attention deficit/hyperactivity disorder
B-cell lymphoma (blood cancer affecting b cells)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Depression
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)

10-19:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fatigue (feeling of tiredness)
Fear
Gallbladder disorder
Injury

20-29:

Pulmonary embolism (blockage of the main artery of the lung)
Chest pain
Dyspnoea (difficult or laboured respiration)
Anxiety
Emotional distress
General physical health deterioration (weak health status)
Injury

30-39:

Abdominal mass (localized enlargement or swelling in the human abdomen)
Haemoglobin decreased
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hepatotoxicity (chemical-driven liver damage)
Intestinal obstruction
Post procedural complication
Renal vein thrombosis (blood clot in renal vein)
Tuberculosis gastrointestinal (a bacterial infection of digestive tract by mycobacterium tuberculosis)
Abdominal hernia
Colitis (inflammation of colon)

40-49:

Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Body temperature increased
Bone disorder
Cardiac amyloidosis (protein deposition in heart)
Cardiac arrest
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

50-59:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac arrest
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Cerebral artery stenosis (hardening of brain blood vessels)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clumsiness (a lack of coordination or elegance)
Coma (state of unconsciousness lasting more than six hours)
Cough

60+:

Asthenia (weakness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Diarrhoea
Failure to thrive (inadequate weight gain and physical growth in children)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Influenza

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 8 people, 15.09%
Multiple Myeloma (cancer of the plasma cells): 5 people, 9.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.43%
Urinary Tract Infection: 3 people, 5.66%
Upper Respiratory Tract Infection: 3 people, 5.66%
Ph Urine Decreased: 3 people, 5.66%
Nausea (feeling of having an urge to vomit): 3 people, 5.66%
Infection: 3 people, 5.66%
Bone Disorder: 3 people, 5.66%
Anaemia (lack of blood): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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