Tylenol w/ codeine no. 3 and Rebif drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate) and Rebif (interferon beta-1a). Common drug interactions include paraesthesia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine no. 3 and Rebif. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

What is Rebif?

Rebif has active ingredients of interferon beta-1a. It is often used in multiple sclerosis. eHealthMe is studying from 61,126 Rebif users. Check the latest studies of Rebif.

On Aug, 04, 2026

16 people who take Tylenol w/ codeine no. 3 and Rebif together, and have interactions are studied.

Tylenol w/ codeine no. 3 and Rebif drug interactions.

What are the common drug interactions of Tylenol W/ Codeine No. 3 and Rebif, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pericarditis (inflammation of the pericardium)
Peripheral coldness
Peripheral ischaemia (impaired circulation to an extremity)
Pyrexia (fever)
Red blood cell count decreased
Type 1 diabetes mellitus
Vomiting
White blood cell count decreased
Fatigue (feeling of tiredness)

male:

Fatigue (feeling of tiredness)
Headache (pain in head)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness
Injection site reaction
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Tylenol W/ Codeine No. 3 and Rebif, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vomiting
Balance disorder
Blindness unilateral
Chest pain
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)
Gait disturbance
Infusion related reaction
Migraine (headache)
Muscle twitching

40-49:

Fatigue (feeling of tiredness)
Abdominal pain
Abdominal discomfort
Aphagia (inability or refusal to swallow)
Asthenia (weakness)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Headache (pain in head)
Influenza like illness

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood potassium decreased
Intestinal obstruction
Migraine (headache)
Pericarditis (inflammation of the pericardium)
Vomiting

60+:

Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Vertigo
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Nephropathy toxic (damage to kidney due to toxins)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal failure acute (rapid kidney dysfunction)
Urinary retention (the inability to completely or partially empty the bladder)

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 31.25%
Itching: 2 people, 12.50%
Optic Neuritis (optic nerve inflammation): 1 person, 6.25%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 6.25%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.25%
Migraine (headache): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
High Blood Cholesterol: 1 person, 6.25%
Depression: 1 person, 6.25%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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