Tylenol w/ codeine no. 4 and Plavix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine no. 4 (acetaminophen; codeine phosphate) and Plavix (clopidogrel bisulfate). Common drug interactions include cyst among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine no. 4 and Plavix. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 4?

Tylenol w/ codeine no. 4 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 460 Tylenol w/ codeine no. 4 users. Check the latest studies of Tylenol w/ codeine no. 4.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,179 Plavix users. Check the latest studies of Plavix.



On Aug, 11, 2026

17 people who take Tylenol w/ codeine no. 4 and Plavix together, and have interactions are studied.

Tylenol w/ codeine no. 4 and Plavix drug interactions.

What are the common drug interactions of Tylenol W/ Codeine No. 4 and Plavix, by gender? *:

female:

  1. Cyst (a closed sac)
  2. Difficulty in walking
  3. Erythema (redness of the skin)
  4. Fall
  5. Feeling hot
  6. Hypersensitivity
  7. Intervertebral disc compression (spinal disc compression)
  8. Lipoma (a growth of fatty tissue that slowly develops just under your skin)
  9. Metastases to bone (cancer spreads to bone)
  10. Myalgia (muscle pain)

male:

  1. Cough
  2. Fall
  3. Dysphagia (a condition in which swallowing is difficult or painful)
  4. Heart rate decreased
  5. Hypoaesthesia (reduced sense of touch or sensation)
  6. Insomnia (sleeplessness)
  7. Nausea (feeling of having an urge to vomit)
  8. Neck pain
  9. Pallor
  10. Pulse pressure decreased

What are the common drug interactions of Tylenol W/ Codeine No. 4 and Plavix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anxiety
  2. Emotional distress
  3. General physical health deterioration (weak health status)
  4. Injury
  5. Joint swelling
  6. Lower extremity mass (mass in lower legs)
  7. Mobility decreased (ability to move is reduced)
  8. Muscle spasms (muscle contraction)
  9. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  10. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

50-59:

  1. Oedema peripheral (superficial swelling)
  2. Pulmonary oedema (fluid accumulation in the lungs)
  3. Pulse abnormal
  4. Red blood cell sedimentation rate increased
  5. Respiratory rate increased (excess breathing rate/min)
  6. Sputum abnormal
  7. Sweating increased (excess sweating)
  8. Syncope (loss of consciousness with an inability to maintain postural tone)
  9. Ventricular extrasystoles (premature cardiac contraction)
  10. Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

60+:

  1. Blood calcium increased
  2. Cardiac failure congestive
  3. Cyst (a closed sac)
  4. Difficulty in walking
  5. Fall
  6. Metastases to bone (cancer spreads to bone)
  7. Myalgia (muscle pain)
  8. Postoperative wound infection
  9. Syncope (loss of consciousness with an inability to maintain postural tone)
  10. Abasia (inability to walk)

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 4 people, 23.53%
  2. Inflammation: 2 people, 11.76%
  3. Urination - Excessive At Night: 1 person, 5.88%
  4. Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 1 person, 5.88%
  5. Enlarged Prostate: 1 person, 5.88%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine no. 4 and Plavix?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tylenol w/ codeine no. 4 and Plavix:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine no. 4:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Plavix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tylenol w/ codeine no. 4 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Plavix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate and clopidogrel bisulfate (the active ingredients of Tylenol w/ codeine no. 4 and Plavix, respectively), and Tylenol w/ codeine no. 4 and Plavix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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