Tylenol w/ codeine and Baclofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Baclofen (baclofen). Common drug interactions include myocardial infarction among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Baclofen. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,662 Baclofen users. Check the latest studies of Baclofen.

On Jul, 18, 2026

100 people who take Tylenol w/ codeine and Baclofen together, and have interactions are studied.

Tylenol w/ codeine and Baclofen drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Baclofen, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anxiety
Chest discomfort
Diarrhoea
Dizziness
Fall
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Influenza like illness
Injection site infection

male:

Dizziness
Anxiety
Bone pain
Bradycardia (abnormally slow heart action)
Completed suicide (act of taking one's own life)
Death
Depression
Dissociative disorder
Dry skin
Dysstasia (difficulty in standing)

What are the common drug interactions of Tylenol W/ Codeine and Baclofen, by age (0-1 to 60+)? *:

0-1:

Foetal movements decreased
Intraventricular haemorrhage neonatal (intraventricular bleeding in newborn)
Premature baby

2-9:

n/a

10-19:

n/a

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspnoea (difficult or laboured respiration)
Eye disorder
Eye inflammation
Eye swelling
Headache (pain in head)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Photophobia (extreme sensitivity to light)
Blood glucose increased
Cardiac disorder

30-39:

Anxiety
Dizziness
Alcoholism (problems with alcohol)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dependence
Drug addiction
Drug maladministration
Headache (pain in head)
Hypertension (high blood pressure)
Infection

40-49:

Asthenia (weakness)
Dizziness
Abdominal pain
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Influenza like illness
Oedema peripheral (superficial swelling)
Vomiting
Diarrhoea
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Syncope (loss of consciousness with an inability to maintain postural tone)
Trichorrhexis (a condition in which the hairs break)
Abdominal discomfort
Abnormal dreams
Abscess limb (limb infection)
Accident
Actinomyces test positive
Activities of daily living impaired
Alcohol use
Alcoholism (problems with alcohol)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Gait disturbance
Injury
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Mobility decreased (ability to move is reduced)
Muscle contracture (a permanent shortening of a muscle)
Muscle tightness

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 24 people, 24.00%
Depression: 8 people, 8.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.00%
High Blood Pressure: 5 people, 5.00%
Headache (pain in head): 5 people, 5.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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