Tylenol w/ codeine and Codeine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Codeine sulfate (codeine sulfate). Common drug interactions include anxiety among females and hepatic neoplasm malignant among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Codeine sulfate. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Codeine sulfate?

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

21 people who take Tylenol w/ codeine and Codeine sulfate together, and have interactions are studied.

Tylenol w/ codeine and Codeine sulfate drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Codeine Sulfate, by gender? *:

female:

Anxiety
Death
Depression
Drug administration error
Fatigue (feeling of tiredness)
Gait disturbance
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

male:

Hepatic neoplasm malignant (liver cancer)
Lung neoplasm malignant (cancer tumour of lung)
Epistaxis (bleed from the nose)
Gastritis (inflammation of stomach)
Pulmonary haemorrhage (acute bleeding from the lung)
Sinusitis (inflammation of sinus)

What are the common drug interactions of Tylenol W/ Codeine and Codeine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug dependence
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Stab wound (a wound due to knife injury or other sharp)
Substance abuse

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Epistaxis (bleed from the nose)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary haemorrhage (acute bleeding from the lung)
Sinusitis (inflammation of sinus)

30-39:

Anxiety
Emotional distress
Fear of disease
Gallbladder non-functioning
Injury
Nausea (feeling of having an urge to vomit)
Psychological trauma
Vomiting

40-49:

n/a

50-59:

Death
Drug administration error
Hepatic neoplasm malignant (liver cancer)
Lung neoplasm malignant (cancer tumour of lung)
Gastritis (inflammation of stomach)

60+:

Arthralgia (joint pain)
Injection site haematoma (localized swelling filled with blood at injection site)
Chills (felling of cold)
Depression
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Fatigue (feeling of tiredness)
Gait disturbance
Haemoglobin decreased
Hemiparesis (weakness on one side of the body)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 19.05%
Osteoporosis (bones weak and more likely to break): 2 people, 9.52%
Migraine (headache): 2 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 9.52%
Abdominal Pain: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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