Tylenol w/ codeine and Enbrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Enbrel (etanercept). Common drug interactions include injection site erythema among females and injection site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Enbrel. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

On Jul, 17, 2026

98 people who take Tylenol w/ codeine and Enbrel together, and have interactions are studied.

Tylenol w/ codeine and Enbrel drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Enbrel, by gender? *:

female:

Injection site erythema (redness at injection site)
Injection site pain
Joint swelling
Pyrexia (fever)
Rash pruritic (redness with itching)
Gestational diabetes (diabetes in pregnancy)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Dizziness
Hallucination (an experience involving the perception of something not present)
Injection site reaction

male:

Injection site pain
Dyspnoea (difficult or laboured respiration)
Hyperhidrosis (abnormally increased sweating)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Interstitial lung disease
Intervertebral disc degeneration (spinal disc degeneration)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pleuritic pain
Premature baby
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Tylenol W/ Codeine and Enbrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

20-29:

Diarrhoea

30-39:

Abortion spontaneous (naturally occurring miscarriage)

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Family stress
Fatigue (feeling of tiredness)
Hilar lymphadenopathy (disease of the lymph nodes due to infection)
Hyperhidrosis (abnormally increased sweating)
Intervertebral disc degeneration (spinal disc degeneration)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pleuritic pain
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Contusion (a type of hematoma of tissue in which capillaries)
Dental caries
Diplopia (double vision)
Dry mouth
Dystonia (abnormal muscle tone)
Ear pain
Fall
Head injury
Injection site erythema (redness at injection site)

60+:

Pneumonia
Oedema peripheral (superficial swelling)
Nasopharyngitis (inflammation of the nasopharynx)
Pain in extremity
Precancerous skin lesion
Rash generalised (rash on most of body parts)
Rash pruritic (redness with itching)
Injection site pain
Insomnia (sleeplessness)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 12 people, 12.24%

* Approximation only. Some reports may have incomplete information.

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