Tylenol w/ codeine and Meridia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Meridia (sibutramine hydrochloride). Common drug interactions include drug ineffective among females and hernia among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Meridia. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Meridia?

Meridia has active ingredients of sibutramine hydrochloride. It is often used in weight loss. eHealthMe is studying from 6,939 Meridia users. Check the latest studies of Meridia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

29 people who take Tylenol w/ codeine and Meridia together, and have interactions are studied.

Tylenol w/ codeine and Meridia drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Meridia, by gender? *:

female:

Drug ineffective
Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Blood pressure increased
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Sedation
Unexpected therapeutic effect
Adult respiratory distress syndrome (type of lung (pulmonary) failure)

male:

Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Malignant melanoma (skin cancer rises from melancytes)
Rash pruritic (redness with itching)
Unexpected therapeutic effect
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Constipation
Drug ineffective
Exfoliative rash (scaly red generalized skin rash)

What are the common drug interactions of Tylenol W/ Codeine and Meridia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Tooth disorder (tooth disease)

30-39:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Headache (pain in head)
Blood pressure increased
Central nervous system stimulation
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Dyspnoea (difficult or laboured respiration)

40-49:

Unexpected therapeutic effect
Pruritus (severe itching of the skin)
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Bladder infection
Blood pressure increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Constipation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

50-59:

Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart rate decreased
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Hypoxia (low oxygen in tissues)
Myalgia (muscle pain)
Po2 decreased
Productive cough
Sedation
Sputum abnormal

60+:

Drug ineffective
Hepatic cyst

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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