Tylenol w/ codeine and Methylprednisolone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Methylprednisolone (methylprednisolone). Common drug interactions include coronary artery occlusion among females and drug addiction among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Methylprednisolone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Methylprednisolone?

Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. eHealthMe is studying from 59,645 Methylprednisolone users. Check the latest studies of Methylprednisolone.

On Jul, 12, 2026

20 people who take Tylenol w/ codeine and Methylprednisolone together, and have interactions are studied.

Tylenol w/ codeine and Methylprednisolone drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Methylprednisolone, by gender? *:

female:

Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed mood
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Diplopia (double vision)
Disinhibition (loss of inhibition)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug ineffective
Dysarthria (speech disorder)
Dizziness

male:

Drug addiction
Dizziness
Insomnia (sleeplessness)
Phobia (fear)
Psychomotor hyperactivity (feelings of extreme restlessness)
Sedation
Smoker
Visual disturbance
Haemoglobin decreased
Post procedural complication

What are the common drug interactions of Tylenol W/ Codeine and Methylprednisolone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug addiction
Self-injurious ideation

30-39:

Confusional state
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dependence
Depressed mood
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Diplopia (double vision)
Disinhibition (loss of inhibition)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug addiction
Faecal incontinence (a lack of control over passing stool)

40-49:

n/a

50-59:

Chest pain
Dehydration (dryness resulting from the removal of water)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)
Vomiting
Haematocrit decreased
Haemoglobin decreased
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)

60+:

Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Drug ineffective
Dysarthria (speech disorder)
Fatigue (feeling of tiredness)
Gait disturbance
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased
Lethargy (tiredness)
Memory impairment

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 20.00%
Oral Cancer (mouth cancer): 2 people, 10.00%
Depression: 2 people, 10.00%
Stress Symptoms: 1 person, 5.00%
Stress And Anxiety: 1 person, 5.00%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.00%
Osteoporosis (bones weak and more likely to break): 1 person, 5.00%
Insomnia (sleeplessness): 1 person, 5.00%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 1 person, 5.00%
High Blood Cholesterol: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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