Tylenol w/ codeine and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Prograf (tacrolimus). Common drug interactions include musculoskeletal stiffness among females and haemoglobin decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Prograf. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 16, 2026

38 people who take Tylenol w/ codeine and Prograf together, and have interactions are studied.

Tylenol w/ codeine and Prograf drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Prograf, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain of skin
Rash
Skin plaque (red, scaly patches to appear on the skin)
Pyrexia (fever)
Anxiety
Emotional distress
Epiphyseal disorder
General physical health deterioration (weak health status)
Kidney transplant rejection

male:

Haemoglobin decreased
Arthralgia (joint pain)
Emotional distress
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Foot deformity (functional disability of foot)
Gait disturbance
General physical health deterioration (weak health status)
Haematocrit decreased

What are the common drug interactions of Tylenol W/ Codeine and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Epiphyseal disorder
Kidney transplant rejection
Postoperative wound complication
Pyrexia (fever)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Balance disorder
Dysstasia (difficulty in standing)
Emotional distress
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Foot deformity (functional disability of foot)

30-39:

Impaired gastric emptying
Injection site bruising
Irritable bowel syndrome
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)
Nausea (feeling of having an urge to vomit)
Vomiting
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Haematocrit decreased
Haemoglobin decreased
Melaena (the passage of black, tarry stools)
Neutropenia (an abnormally low number of neutrophils)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Red blood cell count decreased
Thrombocytopenia (decrease of platelets in blood)
Weight increased
Abdominal pain upper

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Mobility decreased (ability to move is reduced)
Oedema (fluid collection in tissue)
Skin fibrosis (fibrous tissue formation on skin)
Skin hyperpigmentation (disorders affect the colour of your skin)
Scar
Skin exfoliation (removal of the oldest dead skin cells)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness

60+:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Nausea (feeling of having an urge to vomit)
Prerenal failure
Renal failure acute (rapid kidney dysfunction)
Vomiting
Cardiac failure
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 12 people, 31.58%
Nuclear Magnetic Resonance Imaging Abdominal: 9 people, 23.68%
High Blood Cholesterol: 8 people, 21.05%
Stress And Anxiety: 7 people, 18.42%
Nausea (feeling of having an urge to vomit): 7 people, 18.42%
Itching: 7 people, 18.42%
Herpes Zoster: 7 people, 18.42%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 7 people, 18.42%
Device Related Infection: 7 people, 18.42%
Depression: 7 people, 18.42%

* Approximation only. Some reports may have incomplete information.

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